Brand  (β version)

PDB ID: 2C29

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Ligands
Code Name Style Show Link
NAP Nadp nicotinamide-adenine-dinucleotide phosphate PoSSuM
DQH (2r,3r)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-2,3-dihydro-4h-chromen-4-one PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2C29   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Structure of dihydroflavonol reductase from Vitis vinifera at 1.8 A.
Release Data : 2006-10-16
Compound :
mol_id molecule chains
1 DIHYDROFLAVONOL 4-REDUCTASE D,F
ec: 1.1.1.219
other_details: ROSSMANN FOLD
Source :
mol_id organism_scientific organism_common expression_system
1 VITIS VINIFERA  (taxid:29760) GRAPE ESCHERICHIA COLI  (taxid:562)
expression_system_strain: M15(PREP4)
expression_system_plasmid: PQE(30XA)
Authors : Petit, P., Granier, T., D'Estaintot, B.L., Hamdi, S., Gallois, B.
Keywords : FLAVONOIDS, SHORT DEHYDROGENASE REDUCTASE, NADPH, DIHYDROQUERCETIN, ROSSMANN FOLD, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.81 Å )
Citation :

Crystal Structure of Grape Dihydroflavonol 4-Reductase, a Key Enzyme in Flavonoid Biosynthesis.

Petit, P.,Granier, T.,D'Estaintot, B.L.  et al.
(2007)  J.Mol.Biol.  368 : 1345

PubMed: 17395203
DOI: 10.1016/J.JMB.2007.02.088

Reaction

Chain : D, F
UniProt : P93799 (P93799_VITVI)
Reaction: EC: Evidence:
Physiological Direction:
(2S)-flavan-4-ol + NADP(+) = (2S)-flavanone + NADPH + H(+) 1.1.1.234 ARBA:ARBA00048870
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a (2R,3S,4S)-leucoanthocyanidin + NADP(+) = a (2R,3R)- dihydroflavonol + NADPH + H(+) 1.1.1.219 ARBA:ARBA00049132
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