Brand  (β version)

PDB ID: 2C13

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
K Potassium ion PoSSuM
MG Magnesium ion PoSSuM
PEG Di(hydroxyethyl)ether PoSSuM
PGE Triethylene glycol PoSSuM
Non-standard Residues
Code Name Show
FHL (E)-N~6~-[3-carboxy-1-(hydroxymethyl)propylidene]-L-lysine
Glycosylation
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Modification
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Structure summary

Code : 2C13   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : 5-hydroxy-levulinic acid bound to Porphobilinogen synthase from Pseudomonas aeruginosa
Release Data : 2006-06-20
Compound :
mol_id molecule chains synonym
1 DELTA-AMINOLEVULINIC ACID DEHYDRATASE A,B PORPHOBILINOGEN SYNTHASE, ALAD, ALADH
ec: 4.2.1.24
mutation: YES
Source :
mol_id organism_scientific expression_system
1 PSEUDOMONAS AERUGINOSA  (taxid:287) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_vector: PET3A
Authors : Frere, F., Nentwich, M., Gacond, S., Heinz, D.W., Neier, R., Frankenberg-Dinkel, N.
Keywords : ENZYME MECHANISM, METALLOENZYME, PORPHOBILINOGEN SYNTHASE, COCRYSTALLIZATION, LYASE, PORPHYRIN BIOSYNTHESIS
Exp. method : X-RAY DIFFRACTION ( 2.15 Å )
Citation :

Probing the Active Site of Pseudomonas Aeruginosa Porphobilinogen Synthase Using Newly Developed Inhibitors.

Frere, F.,Nentwich, M.,Gacond, S.  et al.
(2006)  Biochemistry  45 : 8243

PubMed: 16819823
DOI: 10.1021/BI052611F

Reaction

Chain : A, B
UniProt : Q59643 (HEM2_PSEAE)
Reaction: EC: Evidence:
Physiological Direction:
2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+) 4.2.1.24 PubMed:16819823
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Cofactor: Evidence: Note:
Mg(2+) ECO:0000269 | PubMed:12079382
ECO:0000269 | PubMed:16819823
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