Brand  (β version)

PDB ID: 2BZS

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Ligands
Code Name Style Show Link
CB1 5-(aziridin-1-yl)-2,4-dinitrobenzamide PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 2BZS   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Binding of anti-cancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex.
Release Data : 2005-09-23
Compound :
mol_id molecule chains synonym
1 NRH DEHYDROGENASE [QUINONE] 2 A,B NRH QUINONE OXIDO-REDUCTASE TYPE 2, QUINONE REDUCTASE 2, QR2, NRH QUINONE OXIDOREDUCTASE 2
ec: 1.6.99.-
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
expression_system_strain: TOP10
expression_system_vector: PMTL1013
expression_system_plasmid: PMTL1015
Authors : Abu Khader, M.M., Heap, J.T., De Matteis, C., Kellam, B., Doughty, S.W., Minton, N., Paoli, M.
Keywords : OXIDOREDUCTASE, NQO2, CB1954, FAD, FLAVOPROTEIN, METAL-BINDING, POLYMORPHISM, ZINC
Exp. method : X-RAY DIFFRACTION ( 2.00 Å )
Citation :

Binding of the Anticancer Prodrug Cb1954 to the Activating Enzyme Nqo2 Revealed by the Crystal Structure of Their Complex.

Abu Khader, M.M.,Heap, J.T.,De Matteis, C.  et al.
(2005)  J.Med.Chem.  48 : 7714

PubMed: 16302811
DOI: 10.1021/JM050730N

Reaction

Chain : A, B
UniProt : P16083 (NQO2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = a quinol + beta-nicotinamide D-riboside 1.10.5.1 PubMed:18579530
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