Het-PDB Navi2 (PDB: 2BYH)

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Ligands
Code	Name		Style	Show	Link
2D7	N-(4-acetylphenyl)-5-(5-chloro-2,4-dihydroxyphenyl)-1h-pyrazole-4-carboxamide				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2BYH

Code :

2BYH PDBj RCSB PDB PDBe

Header :

CHAPERONE

Title :

3-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as Inhibitors of the Hsp90 Molecular Chaperone

Release Data :

2005-10-12

Compound :

mol_id	molecule	chains	synonym
1	HEAT SHOCK PROTEIN HSP90-ALPHA	A	HSP 86
	fragment: N-TERMINAL DOMAIN, RESIDUES 1-235

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	ESCHERICHIA COLI (taxid:469008)
	organ: SKIN tissue: MELANOMA expression_system_strain: BL21(DE3) expression_system_plasmid: PET19

Authors :

Brough, P.A., Barril, X., Beswick, M., Dymock, B.W., Drysdale, M.J., Wright, L., Grant, K., Massey, A., Surgenor, A., Workman, P.

Keywords :

PYRAZOLE, HSP90, CHAPERONE, ATP-BINDING, HEAT SHOCK, NUCLEOTIDE-BINDING, PHOSPHORYLATION

Exp. method :

X-RAY DIFFRACTION ( 1.90 Å )

Citation :

3-(5-Chloro-2,4-Dihydroxyphenyl)-Pyrazole-4-Carboxamides as Inhibitors of the Hsp90 Molecular Chaperone.

Brough, P.A.,Barril, X.,Beswick, M. et al.
(2005) Bioorg.Med.Chem.Lett. 15 : 5197

Chain :

UniProt :

P07900 (HS90A_HUMAN)

PDB ID: 2BYH