Brand  (β version)

PDB ID: 2BVW

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Ligands
Code Name Style Show Link
GOL Glycerol PoSSuM
BGC Beta-D-glucopyranose PoSSuM
: Polysaccharide
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
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Structure summary

Code : 2BVW   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : CELLOBIOHYDROLASE II (CEL6A) FROM HUMICOLA INSOLENS IN COMPLEX WITH GLUCOSE AND CELLOTETRAOSE
Release Data : 2000-02-25
Compound :
mol_id molecule chains synonym
1 CELLOBIOHYDROLASE II A,B CELLULASE, CEL6A
ec: 3.2.1.91
fragment: CATALYTIC CORE DOMAIN
other_details: N-LINKED N-ACETYLGLUCOSAMINE ON RESIDUE ASN 141
Source :
mol_id organism_scientific expression_system
1 Humicola insolens  (taxid:34413) Aspergillus oryzae  (taxid:5062)
expression_system_vector_type: FUNGAL
expression_system_plasmid: UNDER CONTROL OF THE FUNGAL AMYLASE PROMOTER AND AMYLOGLUCOSIDASE TERMINATOR
other_details: FULL-LENGTH ENZYME OVER-EXPRESSED
Authors : Varrot, A., Davies, G.J., Schulein, M.
Keywords : HYDROLASE, CELLULOSE DEGRADATION, CELLOBIOHYDROLASE, CELLULASE, GLYCOSIDE HYDROLASE FAMILY 6
Exp. method : X-RAY DIFFRACTION ( 1.7 Å )
Citation :

Structural changes of the active site tunnel of Humicola insolens cellobiohydrolase, Cel6A, upon oligosaccharide binding.

Varrot, A.,Schulein, M.,Davies, G.J.
(1999)  Biochemistry  38 : 8884 - 8891

PubMed: 10413461
DOI: 10.1021/bi9903998

Reaction

Chain : A, B
UniProt : Q9C1S9 (GUX6_HUMIN)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains. 3.2.1.91 PubMed:9335167
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