Het-PDB Navi2 (PDB: 2BT4)

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Ligands
Code	Name	Link
CA2	(1s,3r,4r,5s)-1,3,4-trihydroxy-5-(3-phenoxypropyl)cyclohexanecarboxylic acid	PoSSuM
GOL	Glycerol	PoSSuM
PO4	Phosphate ion	PoSSuM
TRS	2-amino-2-hydroxymethyl-propane-1,3-diol	PoSSuM

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Download interaction data: 2BT4

Code :

2BT4 PDBj RCSB PDB PDBe

Header :

LYASE

Title :

Type II Dehydroquinase inhibitor complex

Release Data :

2006-02-13

Compound :

mol_id	molecule	chains	synonym
1	3-DEHYDROQUINATE DEHYDRATASE	A,B,C,D,E,F,G,H,I,J,K,L	3-DEHYDROQUINASE, TYPE II DHQASE, TYPE II DEHYDROQUINASE
	ec: 4.2.1.10 other_details: RATIONALLY DESIGNED BIFUNCTIONAL INHIBITOR

Source :

mol_id	organism_scientific	expression_system
1	STREPTOMYCES COELICOLOR (taxid:1902)	ESCHERICHIA COLI (taxid:511693)
	expression_system_strain: BL21 expression_system_vector: PTB361 expression_system_plasmid: PDHQ

Authors :

Toscano, M.D., Stewart, K.A., Coggins, J.R., Lapthorn, A.J., Abell, C.

Keywords :

SHIKIMATE PATHWAY, DEHYDROQUINATE, LYASE, AMINO-ACID BIOSYNTHESIS, AROMATIC AMINO ACID BIOSYNTHESIS

Exp. method :

X-RAY DIFFRACTION ( 1.70 Å )

Citation :

Rational Design of New Bifunctional Inhibitors of Type II Dehydroquinase.

Toscano, M.D.,Stewart, K.A.,Coggins, J.R. et al.
(2005) Org.Biomol.Chem. 3 : 3102

The Structure and Mechanism of the Type II Dehydroquinase from Streptomyces Coelicolor

Roszak, A.W.,Robinson, D.A.,Krell, T. et al.
(2002) Structure 10 : 493

Chain :

A, B, C, D, E, F, G, H, I, J, K, L

UniProt :

P15474 (AROQ_STRCO)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
3-dehydroquinate = 3-dehydroshikimate + H2O	4.2.1.10	-
3-dehydroquinate = 3-dehydroshikimate + H2O	-	-

PDB ID: 2BT4