Brand  (β version)

PDB ID: 2BRC

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Ligands
Code Name Style Show Link
CT5 4-[4-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-methyl-1h-pyrazol-5-yl]-6-ethylbenzene-1,3-diol PoSSuM
Non-standard Residues
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Structure summary

Code : 2BRC   PDBj   RCSB PDB   PDBe
Header : CHAPERONE
Title : Structure of a Hsp90 Inhibitor bound to the N-terminus of Yeast Hsp90.
Release Data : 2005-09-29
Compound :
mol_id molecule chains synonym
1 ATP-DEPENDENT MOLECULAR CHAPERONE HSP82 A HSP90,HEAT SHOCK PROTEIN HSP90,82 KDA HEAT SHOCK PROTEIN
fragment: N-TERMINUS, RESIDUES 1-214
Source :
mol_id organism_scientific organism_common expression_system
1 SACCHAROMYCES CEREVISIAE  (taxid:4932) BAKER'S YEAST ESCHERICHIA COLI  (taxid:562)
Authors : Roe, S.M., Pearl, L.H., Prodromou, C.
Keywords : ATP-BINDING, CHAPERONE, HEAT SHOCK, INHIBITOR, MULTIGENE FAMILY, CHAPERONE-COMPLEX
Exp. method : X-RAY DIFFRACTION ( 1.60 Å )
Citation :

The identification, synthesis, protein crystal structure and in vitro biochemical evaluation of a new 3,4-diarylpyrazole class of Hsp90 inhibitors.

Cheung, K.M.,Matthews, T.P.,James, K.  et al.
(2005)  Bioorg. Med. Chem. Lett.  15 : 3338 - 3343

PubMed: 15955698
DOI: 10.1016/j.bmcl.2005.05.046

Reaction

Chain : A
UniProt : P02829 (HSP82_YEAST)
Reaction : -