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Ligands
Code Name Style Show Link
SAH S-adenosyl-L-homocysteine
Non-standard Residues
Code Name Show
MLZ N-methyl-lysine
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 2BQZ   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Crystal structure of a ternary complex of the human histone methyltransferase Pr-SET7 (also known as SET8)
Release Data : 2005-06-08
Compound :
mol_id molecule chains synonym
1 SET8 PROTEIN A,E HISTONE-LYSINE METHYLTRANSFERASE PR-SET7
ec: 2.1.1.43
fragment: SET-DOMAIN, RESIDUES 192-352
mol_id molecule chains
2 HISTONE H4 B,F
fragment: RESIDUES 17-25
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:562)
mol_id organism_scientific organism_common
2 HOMO SAPIENS  (taxid:9606) HUMAN
synthetic: yes
Authors : Xiao, B., Jing, C., Kelly, G., Walker, P.A., Muskett, F.W., Frenkiel, T.A., Martin, S.R., Sarma, K., Reinberg, D., Gamblin, S.J., Wilson, J.R.
Keywords : HISTONE H4 METHYLTRANSFERSAE, LYSINE METHYLTRANSFERASE, SET DOMAIN, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.50 Å )
Citation :

Specificity and Mechanism of the Histone Methyltransferase Pr-Set7

Xiao, B.,Jing, C.,Kelly, G.  et al.
(2005)  Genes Dev.  19 : 1444

PubMed: 15933069
DOI: 10.1101/GAD.1315905

Chain : A, E
UniProt : Q86W83 (KMT5A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
L-lysyl(20)-[histone H4] + S-adenosyl-L-methionine = H(+) + N(6)-methyl-L-lysyl(20)-[histone H4] + S-adenosyl-L-homocysteine 2.1.1.361 PROSITE-ProRule:PRU00904, PubMed:12086618, PubMed:12121615, PubMed:15964846, PubMed:27338793
-
L-lysyl-[protein] + S-adenosyl-L-methionine = H(+) + N(6)- methyl-L-lysyl-[protein] + S-adenosyl-L-homocysteine - PubMed:17707234
-
Chain : B, F
UniProt : P62805 (H4_HUMAN)
Reaction : -