Brand  (β version)

PDB ID: 2BNN

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Ligands
Code Name Style Show Link
FCN Fosfomycin PoSSuM
ZN Zinc ion PoSSuM
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Structure summary

Code : 2BNN   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : The structure of Hydroxypropylphosphonic acid epoxidase from S. wedmorenis in complex with fosfomycin
Release Data : 2005-10-05
Compound :
mol_id molecule chains synonym
1 EPOXIDASE A,B HYDROXYPROPYLPHOSPHONIC ACID EPOXIDASE
Source :
mol_id organism_scientific expression_system
1 STREPTOMYCES WEDMORENSIS  (taxid:43759) ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_plasmid: PET15B
Authors : McLuskey, K., Cameron, S., Hunter, W.N.
Keywords : OXIDOREDUCTASE, EPOXIDASE, CUPIN, HTH, CATION-DEPENDANT, ZINC, FOSFOMYCIN OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Structure and Reactivity of Hydroxypropylphosphonic Acid Epoxidase in Fosfomycin Biosynthesis by a Cation- and Flavin-Dependent Mechanism.

Mcluskey, K.,Cameron, S.,Hammerschmidt, F.  et al.
(2005)  Proc.Natl.Acad.Sci.USA  102 : 14221

PubMed: 16186494
DOI: 10.1073/PNAS.0504314102

Initiating a Crystallographic Analysis of Recombinant (S)-2-Hydroxypropylphosphonic Acid Epoxidase from Streptomyces Wedmorensis.

Cameron, S.,Mcluskey, K.,Chamberlayne, R.  et al.
(2005)  Acta Crystallogr.,Sect.F  61 : 534

PubMed: 16511089
DOI: 10.1107/S1744309105012376

Reaction

Chain : A, B
UniProt : Q56185 (HPPE_STRWE)
Reaction: EC: Evidence:
Physiological Direction:
(S)-2-hydroxypropylphosphonate + H2O2 = (1R,2S)- epoxypropylphosphonate + 2 H2O 1.11.1.23 PubMed:16015285
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