Brand  (β version)

PDB ID: 2BHJ

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Ligands
Code Name Style Show Link
FC1 Thiocoumarin PoSSuM
HBI 7,8-dihydrobiopterin PoSSuM
HEM Protoporphyrin ix containing Fe PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2BHJ   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : murine iNO synthase with coumarin inhibitor
Release Data : 2005-03-31
Compound :
mol_id molecule chains synonym
1 NITRIC OXIDE SYNTHASE A MURINE INOS, NOS TYPE II, INDUCIBLE NOS, INOS, MACROPHAGE NOS, MAC-NOS
ec: 1.14.13.39
fragment: RESIDUES 77-498, OXYGENASE DOMAIN
Source :
mol_id organism_scientific organism_common expression_system
1 MUS MUSCULUS  (taxid:10090) MOUSE ESCHERICHIA COLI  (taxid:562)
Authors : Mathieu, M., Guilloteau, J.P.
Keywords : INOS, CALMODULIN-BINDING, FAD, FMN, HEME, METAL-BINDING, NADP, OXIDOREDUCTASE, POLYMORPHISM, ZINC
Exp. method : X-RAY DIFFRACTION ( 3.2 Å )
Citation :

Design, Synthesis and Characterization of a Novel Class of Coumarin-Based Inhibitors of Inducible Nitric Oxide Synthase

Jackson, S.A.,Sahni, S.,Lee, L.  et al.
(2005)  Bioorg.Med.Chem.  13 : 2723

PubMed: 15781384
DOI: 10.1016/J.BMC.2005.02.036

Reaction

Chain : A
UniProt : P29477 (NOS2_MOUSE)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide 1.14.13.39 UniProtKB:P35228
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