Brand  (β version)

PDB ID: 2B8O

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Ligands
Code Name Style Show Link
0GJ L-alpha-glutamyl-N-{(1s)-4-{[amino(iminio)methyl]amino}-1-[(1s)-2-chloro-1-hydroxyethyl]butyl}glycinamide PoSSuM
CA Calcium ion PoSSuM
CL Chloride ion PoSSuM
MG Magnesium ion PoSSuM
NA Sodium ion PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
CGU Gamma-carboxy-glutamic acid
Glycosylation
Code Name Emphasize
FUC Alpha-L-fucopyranose
GLC Alpha-D-glucopyranose
Modification
Code Name Show

Structure summary

Code : 2B8O   PDBj   RCSB PDB   PDBe
Header : hydrolase/hydrolase inhibitor
Title : Crystal Structure of Glu-Gly-Arg-Chloromethyl Ketone-Factor VIIa/Soluble Tissue Factor Complex
Release Data : 2007-02-13
Compound :
mol_id molecule chains
1 Coagulation factor VII light chain L
mol_id molecule chains
2 Coagulation factor VII heavy chain H
ec: 3.4.21.21
mol_id molecule chains synonym
3 Tissue factor T TF, Coagulation factor III, Thromboplastin, CD142 antigen
Source :
mol_id organism_scientific organism_common
1 Homo sapiens  (taxid:9606) Human
gene: F7
mol_id organism_scientific organism_common
2 Homo sapiens  (taxid:9606) Human
gene: F7
mol_id organism_scientific organism_common
3 Homo sapiens  (taxid:9606) Human
gene: F3
Authors : Bajaj, S.P., Schmidt, A.E., Padmanabhan, K.
Keywords : Serine protease, Tissue factor, EGR, blood coagualtion, clotting, clotting factor, coagulation factor, hydrolase-hydrolase inhibitor COMPLEX
Exp. method : X-RAY DIFFRACTION ( 2.8 Å )
Citation :

Crystal Structure of Factor VIIa/soluble Tissue Factor complexed with Glu-Gly-Arg-Chloromethyl ketone

Bajaj, S.P.,Schmidt, A.E.,Padmanabhan, K.
To be published 

Reaction

Chain : H
UniProt : P08709 (FA7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa. 3.4.21.21 -
-
Chain : T
UniProt : P13726 (TF_HUMAN)
Reaction : -