Brand  (β version)

PDB ID: 2B7O

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Ligands
Code Name Style Show Link
CE1 O-dodecanyl octaethylene glycol PoSSuM
MN Manganese (II) ion PoSSuM
PEP Phosphoenolpyruvate PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
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MSE Selenomethionine
Glycosylation
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Structure summary

Code : 2B7O   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : The Structure of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase from Mycobacterium tuberculosis
Release Data : 2005-10-18
Compound :
mol_id molecule chains synonym
1 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG A,B DAH7PS, DAHP synthetase, phenylalanine-repressible
ec: 2.5.1.54
Source :
mol_id organism_scientific expression_system
1 Mycobacterium tuberculosis  (taxid:83332) Escherichia coli  (taxid:562)
strain: H37Rv
gene: Rv2178c
expression_system_strain: DL41 (DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pProExHTa
Authors : Webby, C.J., Baker, H.M., Lott, J.S., Baker, E.N., Parker, E.J., Mycobacterium Tuberculosis Structural Proteomics Project (XMTB)
Keywords : Mycobacterium tuberculosis, DAH7PS synthase, Shikimate pathway, aromatic biosynthesis, evolutionary relationships, Structural Genomics, Mycobacterium Tuberculosis Structural Proteomics Project, XMTB, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.30 Å )
Citation :

The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes

Webby, C.J.,Baker, H.M.,Lott, J.S.  et al.
(2005)  J.Mol.Biol.  354 : 927 - 939

PubMed: 16288916
DOI: 10.1016/j.jmb.2005.09.093

Reaction

Chain : A, B
UniProt : O53512 (AROG_MYCTU)
Reaction: EC: Evidence:
Physiological Direction:
D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7- phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate 2.5.1.54 PubMed:16288916
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