Het-PDB Navi2 (PDB: 2B7D)

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Ligands
Code	Name		Style	Show	Link
C1B	(2r)-2-[5-(5-carbamimidoyl-1h-benzoimidazol-2-yl)-6,2'-dihydroxy-5'-ureidomethyl-biphenyl-3-yl]-succinic acid				PoSSuM

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Download interaction data: 2B7D

Code :

2B7D PDBj RCSB PDB PDBe

Header :

BLOOD CLOTTING

Title :

Factor VIIa Inhibitors: Chemical Optimization, Preclinical Pharmacokinetics, Pharmacodynamics, and Efficacy in a Baboon Thrombosis Model

Release Data :

2006-02-14

Compound :

mol_id	molecule	chains	synonym
1	Coagulation factor VII	L	Serum prothrombin conversion accelerator, SPCA, Proconvertin, Eptacog alfa
	fragment: light chain

mol_id	molecule	chains	synonym
2	Coagulation factor VII	H	Serum prothrombin conversion accelerator, SPCA, Proconvertin, Eptacog alfa
	ec: 3.4.21.21 fragment: heavy chain

mol_id	molecule	chains	synonym
3	Tissue factor	T	TF, Coagulation factor III, Thromboplastin, CD142 antigen

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	gene: F7 expression_system_common: Human expression_system_cell_line: HEK 293 expression_system_atcc_number: CRL-1573

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Homo sapiens (taxid:9606)
	gene: F7 expression_system_common: Human expression_system_cell_line: HEK 293 expression_system_atcc_number: CRL-1573

mol_id	organism_scientific	organism_common	expression_system
3	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	gene: F3

Authors :

Young, W.B., Mordenti, J., Torkelson, S., Shrader, W.D., Kolesnikov, A., Rai, R., Liu, L., Hu, H., Leahy, E.M., Green, M.J., Sprengeler, P.A., Katz, B.A., Yu, C., Janc, J.W., Elrod, K.C., Marzec, U.M., Hanson, S.R.

Keywords :

short hydrogen bond, BLOOD CLOTTING

Exp. method :

X-RAY DIFFRACTION ( 2.24 Å )

Citation :

Factor VIIa inhibitors: Chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model.

Young, W.B.,Mordenti, J.,Torkelson, S. et al.
(2006) Bioorg.Med.Chem.Lett. 16 : 2037 - 2041

PubMed: 16412633
DOI: 10.1016/j.bmcl.2005.12.059

Chain :

UniProt :

P08709 (FA7_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Selective cleavage of Arg-\|-Ile bond in factor X to form factor Xa.	3.4.21.21	-
	-	-

Chain :	T
UniProt :	P13726 (TF_HUMAN)
Reaction :	-

PDB ID: 2B7D

Hetero Atom Contents

Structure summary

Reaction