Het-PDB Navi2 (PDB: 2B0U)

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Ligands
Code	Name	Link
IR3	Iridium (III) ion	PoSSuM
MLI	Malonate ion	PoSSuM
MPD	(4s)-2-methyl-2,4-pentanediol	PoSSuM

Non-standard Residues
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Download interaction data: 2B0U

Code :

2B0U PDBj RCSB PDB PDBe

Header :

SIGNALING PROTEIN

Title :

The Structure of the Follistatin:Activin Complex

Release Data :

2005-10-11

Compound :

mol_id	molecule	chains	synonym
1	Inhibin beta A chain	A,B	Activin beta-A chain, Erythroid differentiation protein, EDF
	fragment: Activin (mature form)

mol_id	molecule	chains	synonym
2	Follistatin	C,D	FS, Activin-binding protein
	fragment: Follistatin-288

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Cricetulus griseus (taxid:10029)
	gene: INHBA expression_system_common: Chinese hamster expression_system_cell: Ovary expression_system_vector_type: plasmid

mol_id	organism_scientific	organism_common	expression_system
2	Homo sapiens (taxid:9606)	Human	Cricetulus griseus (taxid:10029)
	gene: FST expression_system_common: Chinese hamster expression_system_cell: Ovary expression_system_vector_type: plasmid

Authors :

Thompson, T.B., Lerch, T.F., Cook, R.W., Woodruff, T.K., Jardetzky, T.S.

Keywords :

activin, follistatin, TGF-beta, morphogen, inhibin, SIGNALING PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.800 Å )

Citation :

The Structure of the Follistatin:Activin Complex Reveals Antagonism of Both Type I and Type II Receptor Binding.

Thompson, T.B.,Lerch, T.F.,Cook, R.W. et al.
(2005) Dev.Cell 9 : 535 - 543

PDB ID: 2B0U