Brand  (β version)

PDB ID: 2AZY

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CHD Cholic acid PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 2AZY   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of Porcine Pancreatic Phospholipase A2 in Complex with Cholate
Release Data : 2006-11-14
Compound :
mol_id molecule chains synonym
1 Phospholipase A2, major isoenzyme A Phosphatidylcholine 2-acylhydrolase, Group IB phospholipase A2
ec: 3.1.1.4
Source :
mol_id organism_scientific organism_common expression_system
1 Sus scrofa  (taxid:9823) Pig Escherichia coli  (taxid:562)
Authors : Pan, Y.H., Bahnson, B.J., Jain, M.K.
Keywords : Bile salt, cholate, CARBOXYLIC ESTER HYDROLASE, PLA2, Pancreatic Enzyme, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.900 Å )
Citation :

Structural basis for bile salt inhibition of pancreatic phospholipase A2.

Pan, Y.H.,Bahnson, B.J.
(2007)  J.Mol.Biol.  369 : 439 - 450

PubMed: 17434532
DOI: 10.1016/j.jmb.2007.03.034

Reaction

Chain : A
UniProt : P00592 (PA21B_PIG)
Reaction: EC: Evidence:
Physiological Direction:
a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- glycero-3-phosphocholine + a fatty acid + H(+) 3.1.1.4 PROSITE-ProRule:PRU10035, PROSITE- ProRule:PRU10036, PubMed:17603006
-
1,2-ditetradecanoyl-sn-glycero-3-phosphocholine + H2O = 2- tetradecanoyl-sn-glycero-3-phosphocholine + H(+) + tetradecanoate - PubMed:17603006
-
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+) + hexadecanoate - UniProtKB:P04055
left-to-right
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero-3- phosphocholine + H(+) - UniProtKB:P04054
left-to-right
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero- 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1- hexadecanoyl-sn-glycero-3-phosphocholine + H(+) - UniProtKB:P04055
left-to-right
1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'- sn-glycerol) + H2O = (9Z)-octadecenoate + 1-hexadecanoyl-sn-glycero- 3-phospho-(1'-sn-glycerol) + H(+) - UniProtKB:P04054
left-to-right
H2O + N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3- phosphoethanolamine = (9Z)-octadecenoate + H(+) + N-hexadecanoyl-1- (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine - UniProtKB:P04055
left-to-right
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3- phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1- hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) - UniProtKB:P04055
left-to-right
H2O + N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn- glycero-3-phosphoethanolamine = (9Z,12Z)-octadecadienoate + H(+) + N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine - UniProtKB:P04055
left-to-right