Het-PDB Navi2 (PDB: 2AZR)

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Ligands
Code	Name		Style	Show	Link
982	3-(carboxymethoxy)thieno[2,3-B]pyridine-2-carboxylic acid				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2AZR

Code :

2AZR PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of PTP1B with Bicyclic Thiophene inhibitor

Release Data :

2005-12-06

Compound :

mol_id	molecule	chains	synonym
1	Tyrosine-protein phosphatase, non-receptor type 1	A	Protein-tyrosine phosphatase 1B, PTP-1B
	ec: 3.1.3.48 fragment: Catalytic Domain, residues 1-299

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21 (taxid:511693)
	gene: PTPN1, PTP1B expression_system_strain: BL21 expression_system_vector_type: plasmid expression_system_plasmid: pET

Authors :

Moretto, A.F., Kirincich, S.J., Xu, W.X., Smith, M.J., Wan, Z.K., Wilson, D.P., Follows, B.C., Binnun, E., Joseph-McCarthy, D., Foreman, K., Erbe, D.V., Zhang, Y.L., Tam, S.K., Tam, S.Y., Lee, J.

Keywords :

Protein tyrosine phosphatase, Hydrolyase, Bicyclic Thiophenes, HYDROLASE

Exp. method :

X-RAY DIFFRACTION ( 2.0 Å )

Citation :

Bicyclic and tricyclic thiophenes as protein tyrosine phosphatase 1B inhibitors.

Moretto, A.F.,Kirincich, S.J.,Xu, W.X. et al.
(2006) Bioorg.Med.Chem. 14 : 2162 - 2177

PubMed: 16303309
DOI: 10.1016/j.bmc.2005.11.005

Chain :

UniProt :

P18031 (PTN1_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate	3.1.3.48	PROSITE- ProRule:PRU10044
	-	PROSITE- ProRule:PRU10044

PDB ID: 2AZR

Hetero Atom Contents

Structure summary

Reaction