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Ligands
Code Name Style Show Link
FLP Flurbiprofen
GOL Glycerol
MNH Manganese protoporphyrin ix
BOG Octyl beta-D-glucopyranoside
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
MAN Alpha-D-mannopyranose
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
Modification
Code Name Show
Code : 2AYL   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : 2.0 Angstrom Crystal Structure of Manganese Protoporphyrin IX-reconstituted Ovine Prostaglandin H2 Synthase-1 Complexed With Flurbiprofen
Release Data : 2006-01-24
Compound :
mol_id molecule chains synonym
1 Prostaglandin G/H synthase 1 A,B Cyclooxygenase-1, COX-1, Prostaglandin-endoperoxide synthase 1, Prostaglandin H2 synthase 1, PGH synthase 1, PGHS-1, PHS 1
ec: 1.14.99.1
Source :
mol_id organism_scientific organism_common
1 Ovis aries  (taxid:9940) Sheep
organ: Seminal Vesicle
Authors : Gupta, K., Selinsky, B.S., Loll, P.J.
Keywords : cyclooxygenase, non-steroidal anti-inflammatory drug, peroxidase, prostaglandin synthase, egf-like domain, membrane binding domain, maganese protoporphyrin IX, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.000 Å )
Citation :

2.0 angstroms structure of prostaglandin H2 synthase-1 reconstituted with a manganese porphyrin cofactor.

Gupta, K.,Selinsky, B.S.,Loll, P.J.
(2006)  Acta Crystallogr.,Sect.D  62 : 151 - 156

PubMed: 16421446
DOI: 10.1107/S0907444905036309

Chain : A, B
UniProt : P05979 (PGH1_SHEEP)
Reaction: EC: Evidence:
Physiological Direction:
(5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2 1.14.99.1 PubMed:7947975
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(5Z,8Z,11Z,14Z)-eicosatetraenoate + 2 O2 = prostaglandin G2 - PubMed:7947975
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AH2 + prostaglandin G2 = A + H2O + prostaglandin H2 - PubMed:7947975
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(9Z,12Z)-octadecadienoate + AH2 + O2 = (9R)-hydroxy-(10E,12Z)- octadecadienoate + A + H2O - PubMed:9448728
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(9Z,12Z)-octadecadienoate + AH2 + O2 = (9S)-hydroxy-(10E,12Z)- octadecadienoate + A + H2O - PubMed:9448728
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(9Z,12Z)-octadecadienoate + AH2 + O2 = (13S)-hydroxy-(9Z,11E)- octadecadienoate + A + H2O - PubMed:9448728
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(9Z,12Z)-octadecadienoate + AH2 + O2 = (13R)-hydroxy-(9Z,11E)- octadecadienoate + A + H2O - PubMed:9448728
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