Brand  (β version)

PDB ID: 2ATS

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
DLY D-lysine PoSSuM
K Potassium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2ATS   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Dihydrodipicolinate synthase co-crystallised with (S)-lysine
Release Data : 2006-09-19
Compound :
mol_id molecule chains
1 dihydrodipicolinate synthase A,B
ec: 4.2.1.52
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
Authors : Devenish, S.R.A., Dobson, R.C.J., Jameson, G.B., Gerrard, J.A.
Keywords : dihydrodipicolinate synthase, DHDPS, lysine, inhibition, LYASE
Exp. method : X-RAY DIFFRACTION ( 1.90 Å )
Citation :

The co-crystallisation of (S)-lysine-bound dihydrodipicolinate synthase from E. coli indicates that domain movements are not responsible for (S)-lysine inhibition

Devenish, S.R.A.,Dobson, R.C.J.,Jameson, G.B.  et al.
To be published 

Reaction

Chain : A, B
UniProt : P0A6L2 (DAPA_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy- 2,3,4,5-tetrahydrodipicolinate + H(+) + H2O 4.3.3.7 HAMAP-Rule:MF_00418, PubMed:20503968, PubMed:8993314
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