Brand  (β version)

PDB ID: 2AR8

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
CTE 7-chlorotryptophan PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2AR8   PDBj   RCSB PDB   PDBe
Header : BIOSYNTHETIC PROTEIN
Title : The structure of tryptophan 7-halogenase (PrnA)suggests a mechanism for regioselective chlorination
Release Data : 2005-10-04
Compound :
mol_id molecule chains
1 tryptophan halogenase PrnA A
Source :
mol_id organism_scientific expression_system
1 Pseudomonas fluorescens  (taxid:294) Pseudomonas fluorescens  (taxid:294)
gene: PrnA
expression_system_strain: Pseudomonas fluorescens BL915
expression_system_vector_type: plasmid
expression_system_plasmid: pPEH14
Authors : Dong, C., Flecks, S., Unversucht, S., Haupt, C., Van Pee, K.H., Naismith, J.H., Scottish Structural Proteomics Facility (SSPF)
Keywords : tryptophan 7-halogenase, flavin-dependent halogenase, helical bundle, sandwiched sheets, Structural Genomics, Scottish Structural Proteomics Facility, SSPF, BIOSYNTHETIC PROTEIN
Exp. method : X-RAY DIFFRACTION ( 2.200 Å )
Citation :

Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination.

Dong, C.,Flecks, S.,Unversucht, S.  et al.
(2005)  Science  309 : 2216 - 2219

PubMed: 16195462
DOI: 10.1126/science.1116510

Crystallization and X-ray diffraction of a halogenating enzyme, tryptophan 7-halogenase, from Pseudomonas fluorescens

Dong, C.,Kotzsch, A.,Dorward, M.  et al.
(2004)  Acta Crystallogr.,Sect.D  60 : 1438 - 1440

PubMed: 15272170
DOI: 10.1107/S0907444904012521

Reaction

Chain : A
UniProt : P95480 (TRP7H_PSEFL)
Reaction: EC: Evidence:
Physiological Direction:
L-tryptophan + FADH2 + chloride + O2 = 7-chloro-L-tryptophan + FAD + 2 H2O 1.14.19.9 PubMed:33465708, PubMed:9537395
left-to-right PubMed:9537395