Brand  (β version)

PDB ID: 2AOU

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Ligands
Code Name Style Show Link
CQA 4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol PoSSuM
Non-standard Residues
Code Name Show
CSO S-hydroxycysteine
DCY D-cysteine
Glycosylation
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Structure summary

Code : 2AOU   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Histamine Methyltransferase Complexed with the Antimalarial Drug Amodiaquine
Release Data : 2005-09-13
Compound :
mol_id molecule chains synonym
1 Histamine N-methyltransferase A HMT
ec: 2.1.1.8
mol_id molecule chains
2 Histamine N-methyltransferase B
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HNMT
expression_system_strain: DH5A
expression_system_vector_type: PLASMID
expression_system_plasmid: PGEX-4T-3
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: HNMT
expression_system_strain: DH5A
expression_system_vector_type: PLASMID
expression_system_plasmid: PGEX-4T-3
Authors : Horton, J.R., Sawada, K., Nishibori, M., Cheng, X.
Keywords : CLASSIC METHYLTRANSFERASE FOLD, PROTEIN-DRUG COMPLEX, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.3 Å )
Citation :

Structural basis for inhibition of histamine N-methyltransferase by diverse drugs

Horton, J.R.,Sawada, K.,Nishibori, M.  et al.
(2005)  J.Mol.Biol.  353 : 334 - 344

PubMed: 16168438
DOI: 10.1016/j.jmb.2005.08.040

Polymorphic Forms of Human Histamine Methyltransferase: Structural, Thermal, and Kinetic Comparisons

Horton, J.R.,Sawada, K.,Nishibori, M.  et al.
(2001)  Structure  9 : 837 - 849

Reaction

Chain : B
UniProt : P50135 (HNMT_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
histamine + S-adenosyl-L-methionine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H(+) 2.1.1.8 PROSITE-ProRule:PRU00929, PubMed:26206890
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