Het-PDB Navi2 (PDB: 2ANJ)

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Ligands
Code	Name		Style	Show	Link
KAI	3-(carboxymethyl)-4-isopropenylproline				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 2ANJ

Code :

2ANJ PDBj RCSB PDB PDBe

Header :

MEMBRANE PROTEIN

Title :

Crystal Structure of the Glur2 Ligand Binding Core (S1S2J-Y450W) Mutant in Complex With the Partial Agonist Kainic Acid at 2.1 A Resolution

Release Data :

2005-08-30

Compound :

mol_id	molecule	chains	synonym
1	Glutamate receptor 2	A	GluR-2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2
	fragment: Ligand Binding Core mutation: Y61W

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Rattus norvegicus (taxid:10116)	Norway rat	Escherichia coli BL21(DE3) (taxid:469008)
	gene: Gria2, Glur2 expression_system_strain: BL21(DE3) expression_system_vector_type: Plasmid expression_system_plasmid: pETGQ

Authors :

Holm, M.M., Naur, P., Vestergaard, B., Geballe, M.T., Gajhede, M., Kastrup, J.S., Traynelis, S.F., Egebjerg, J.

Keywords :

Ionotropic Glutamate Receptor, GluR2 Ligand-Binding Core, Agonist Complex, Mutant, MEMBRANE PROTEIN

Exp. method :

X-RAY DIFFRACTION ( 2.10 Å )

Citation :

A Binding Site Tyrosine Shapes Desensitization Kinetics and Agonist Potency at GluR2: a mutagenic, kinetic, and crystallographic study

Holm, M.M.,Naur, P.,Vestergaard, B. et al.
(2005) J.Biol.Chem. 280 : 35469 - 35476

Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.

Armstrong, N.,Gouaux, E.
(2000) Neuron 28 : 165 - 181

Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2.

Frandsen, A.,Pickering, D.S.,Vestergaard, B. et al.
(2005) Mol.Pharmacol. 67 : 703 - 713

Tuning Activation of the Ampa-Sensitive Glur2 Ion Channel by Genetic Adjustment of Agonist-Induced

Armstrong, N.,Mayer, M.,Gouaux, E.
(2003) Proc.Natl.Acad.Sci.USA 100 : 5736

PDB ID: 2ANJ