Brand  (β version)

PDB ID: 2AJB

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Ligands
Code Name Style Show Link
0QG 3-methyl-L-valyl-L-prolyl-L-isoleucine PoSSuM
SO4 Sulfate ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
NAG 2-acetamido-2-deoxy-beta-D-glucopyranose
BMA Beta-D-mannopyranose
Modification
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Structure summary

Code : 2AJB   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : Porcine dipeptidyl peptidase IV (CD26) in complex with the tripeptide tert-butyl-Gly-L-Pro-L-Ile (tBu-GPI)
Release Data : 2006-02-28
Compound :
mol_id molecule chains synonym
1 Dipeptidyl peptidase 4 A,B,C,D Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26
ec: 3.4.14.5
fragment: Extracellular domain
Source :
mol_id organism_scientific organism_common
1 Sus scrofa  (taxid:9823) Pig
organ: Kidney
Authors : Engel, M., Hoffmann, T., Manhart, S., Heiser, U., Chambre, S., Huber, R., Demuth, H.U., Bode, W.
Keywords : Serine protease, dipeptidyl peptidase, alpha/beta-hydrolase, beta-propeller, oxyanion hole, substrate channeling, drug design, diabetes mellitus, flexibility, hydrolase-hydrolase inhibitor complex
Exp. method : X-RAY DIFFRACTION ( 2.750 Å )
Citation :

Rigidity and flexibility of dipeptidyl peptidase IV: crystal structures of and docking experiments with DPIV.

Engel, M.,Hoffmann, T.,Manhart, S.  et al.
(2006)  J.Mol.Biol.  355 : 768 - 783

PubMed: 16330047
DOI: 10.1016/j.jmb.2005.11.014

Reaction

Chain : A, B, C, D
UniProt : P22411 (DPP4_PIG)
Reaction: EC: Evidence:
Physiological Direction:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline. 3.4.14.5 UniProtKB:P27487, PROSITE- ProRule:PRU10084
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