Brand  (β version)

PDB ID: 2AH2

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Ligands
Code Name Style Show Link
CL Chloride ion PoSSuM
GOL Glycerol PoSSuM
IPA Isopropyl alcohol PoSSuM
FSI 5-acetamido-3,5-dideoxy-3-fluoro-D-erythro-alpha-L-manno-non-2-ulopyranosonic acid PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 2AH2   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Trypanosoma cruzi trans-sialidase in complex with 2,3-difluorosialic acid (covalent intermediate)
Release Data : 2005-08-23
Compound :
mol_id molecule chains
1 trans-sialidase A
ec: 3.2.1.18
mutation: N59F, S496K, V497G, E521K, D594G, I598D, H600R
Source :
mol_id organism_scientific expression_system
1 Trypanosoma cruzi  (taxid:5693) Escherichia coli  (taxid:562)
expression_system_strain: TOP10F'
expression_system_vector_type: plasmid
expression_system_plasmid: pTrcHisA
Authors : Amaya, M.F., Watts, A.G., Damager, I., Wehenkel, A., Nguyen, T., Buschiazzo, A., Paris, G., Frasch, A.C., Withers, S.G., Alzari, P.M.
Keywords : transglycosidase, covalent intermediate, trypanosoma cruzi, sialic acid, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.600 Å )
Citation :

Structural Insights into the Catalytic Mechanism of Trypanosoma cruzi trans-Sialidase

Amaya, M.F.,Watts, A.G.,Damager, I.  et al.
(2004)  Structure  12 : 775 - 784

PubMed: 15130470
DOI: 10.1016/j.str.2004.02.036

Reaction

Chain : A
UniProt : Q26966 (Q26966_TRYCR)
Reaction : -