Brand  (β version)

PDB ID: 2AEI

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Ligands
Code Name Style Show Link
03R 2-({6-{3-[amino(imino)methyl]phenoxy}-3,5-difluoro-4-[(1-methyl-3-phenylpropyl)amino]-2-pyridinyl}oxy)benzoic acid PoSSuM
CA Calcium ion PoSSuM
CAC Cacodylate ion PoSSuM
Non-standard Residues
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CGU Gamma-carboxy-glutamic acid
Glycosylation
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Structure summary

Code : 2AEI   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of a ternary complex of factor VIIa/tissue factor and 2-[[6-[3-(aminoiminomethyl)phenoxy]-3,5-difluro-4-[(1-methyl-3-phenylpropyl)amino]-2-pyridinyl]oxy]-benzoic acid
Release Data : 2006-08-01
Compound :
mol_id molecule chains synonym
1 Coagulation factor VII L Serum prothrombin conversion accelerator, SPCA, Proconvertin, Eptacog alfa
ec: 3.4.21.21
fragment: LIGHT CHAIN
mol_id molecule chains synonym
2 Coagulation factor VII H Serum prothrombin conversion accelerator, SPCA, Proconvertin, Eptacog alfa
ec: 3.4.21.21
fragment: HEAVY CHAIN
mol_id molecule chains synonym
3 Tissue factor T TF, Coagulation factor III, Thromboplastin, CD142 antigen
fragment: RESIDUES 33-243
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
gene: F7
expression_system_common: Chinese hamster
expression_system_organ: kidney
mol_id organism_scientific organism_common expression_system
2 Homo sapiens  (taxid:9606) Human Cricetulus griseus  (taxid:10029)
gene: F7
expression_system_common: Chinese hamster
expression_system_organ: kidney
mol_id organism_scientific organism_common expression_system
3 Homo sapiens  (taxid:9606) Human Saccharomyces cerevisiae  (taxid:4932)
gene: F3
expression_system_common: Baker's yeast
Authors : Adler, M., Whitlow, M.
Keywords : BLOOD COAGULATION, SERINE PROTEASE, THROMBOSIS, GLA, PYRIDINE, BENZAMIDINE, TISSUE FACTOR, COFACTOR, ENZYME INHIBITOR COMPLEX, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.52 Å )
Citation :

The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex.

Kohrt, J.T.,Filipski, K.J.,Cody, W.L.  et al.
(2005)  Bioorg.Med.Chem.Lett.  15 : 4752 - 4756

PubMed: 16125385
DOI: 10.1016/j.bmcl.2005.07.059

Reaction

Chain : H
UniProt : P08709 (FA7_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa. 3.4.21.21 -
-
Chain : T
UniProt : P13726 (TF_HUMAN)
Reaction : -