Brand  (β version)

PDB ID: 2ACZ

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Ligands
Code Name Style Show Link
AT5 3-[(2s,4s,5r)-5,6-dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1h)-pyridinone PoSSuM
CDN Cardiolipin PoSSuM
F3S Fe3-s4 cluster PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
FES Fe2/s2 (inorganic) cluster PoSSuM
HEB Heme B/C PoSSuM
OAA Oxaloacetate ion PoSSuM
SF4 Iron/sulfur cluster PoSSuM
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Structure summary

Code : 2ACZ   PDBj   RCSB PDB   PDBe
Header : Oxidoreductase/Electron transport
Title : Complex II (Succinate Dehydrogenase) From E. Coli with Atpenin A5 inhibitor co-crystallized at the ubiquinone binding site
Release Data : 2006-01-03
Compound :
mol_id molecule chains
1 Succinate dehydrogenase flavoprotein subunit A
ec: 1.3.99.1
mol_id molecule chains
2 Succinate dehydrogenase iron-sulfur protein B
ec: 1.3.99.1
mol_id molecule chains synonym
3 Succinate dehydrogenase cytochrome b556 subunit C Cytochrome b-556
mol_id molecule chains
4 Succinate dehydrogenase hydrophobic membrane anchor protein D
Source :
mol_id organism_scientific expression_system
1 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_strain: DW35
expression_system_vector_type: plasmid
expression_system_plasmid: pFAS
mol_id organism_scientific expression_system
2 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_strain: DW35
expression_system_vector_type: plasmid
expression_system_plasmid: pFAS
mol_id organism_scientific expression_system
3 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_strain: DW35
expression_system_vector_type: plasmid
expression_system_plasmid: pFAS
mol_id organism_scientific expression_system
4 Escherichia coli  (taxid:562) Escherichia coli  (taxid:562)
expression_system_strain: DW35
expression_system_vector_type: plasmid
expression_system_plasmid: pFAS
Authors : Horsefield, R., Yankovskaya, V., Sexton, G., Whittingham, W., Shiomi, K., Omura, S., Byrne, B., Cecchini, G., Iwata, S.
Keywords : MEMBRANE PROTEIN, Aerobic reparatory Complex II, SQR, succinate:ubiquinone oxidoreductase, AA5, AT5, Atpenin A5, SDH, succinate dehydrogenase, Oxidoreductase-Electron transport COMPLEX
Exp. method : X-RAY DIFFRACTION ( 3.1 Å )
Citation :

Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction.

Horsefield, R.,Yankovskaya, V.,Sexton, G.  et al.
(2006)  J.Biol.Chem.  281 : 7309 - 7316

PubMed: 16407191
DOI: 10.1074/jbc.M508173200

Reaction

Chain : A
UniProt : P10444 (SDHA_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
a quinone + succinate = fumarate + a quinol 1.3.5.1 PubMed:19710024
-
Cofactor: Evidence: Note:
FAD ECO:0000269 | PubMed:12560550
ECO:0000269 | PubMed:16407191
ECO:0000269 | PubMed:19710024
Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.
Chain : B
UniProt : P07014 (SDHB_ECOLI)
Reaction: EC: Evidence:
Physiological Direction:
a quinone + succinate = fumarate + a quinol 1.3.5.1 -
-
Cofactor: Evidence: Note:
[2Fe-2S] cluster - Binds 1 [2Fe-2S] cluster.
[3Fe-4S] cluster - Binds 1 [3Fe-4S] cluster.
[4Fe-4S] cluster - Binds 1 [4Fe-4S] cluster.
Chain : C
UniProt : P69054 (DHSC_ECOLI)
Reaction : -
Cofactor: Evidence: Note:
heme - The heme is bound between the two transmembrane subunits.
Chain : D
UniProt : P10445 (DHSD_ECOLI)
Reaction : -
Cofactor: Evidence: Note:
heme - The heme is bound between the two transmembrane subunits.