Brand  (β version)

PDB ID: 2A57

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Ligands
Code Name Style Show Link
CRM 3-[8-((2s,3s,4r)-2,3,4,5-tetrahydroxypentyl)-2,4,7-trioxo-1,3,8-trihydropteridin-6-yl]propanoic acid PoSSuM
PO4 Phosphate ion PoSSuM
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Structure summary

Code : 2A57   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structure of 6,7-Dimthyl-8-ribityllumazine synthase from Schizosaccharomyces pombe mutant W27Y with bound ligand 6-carboxyethyl-7-oxo-8-ribityllumazine
Release Data : 2005-07-19
Compound :
mol_id molecule chains synonym
1 6,7-dimethyl-8-ribityllumazine synthase A,B,C,D,E DMRL synthase, Lumazine synthase, Riboflavin synthase beta chain
ec: 2.5.1.78
mutation: W27Y
Source :
mol_id organism_scientific organism_common expression_system
1 Schizosaccharomyces pombe  (taxid:4896) Fission yeast Escherichia coli  (taxid:562)
gene: rib4
Authors : Koch, M., Breithaupt, C., Gerhardt, S., Haase, I., Weber, S., Cushman, M., Huber, R., Bacher, A., Fischer, M.
Keywords : 6, 7-dimethyl-8-ribityllumazine synthase, riboflavin, riboflavin biosynthesis, LUSY, Transferase
Exp. method : X-RAY DIFFRACTION ( 2.750 Å )
Citation :

Structural basis of charge transfer complex formation by riboflavin bound to 6,7-dimethyl-8-ribityllumazine synthase

Koch, M.,Breithaupt, C.,Gerhardt, S.  et al.
(2004)  Eur.J.Biochem.  271 : 3208 - 3214

PubMed: 15265040
DOI: 10.1111/j.1432-1033.2004.04253.x

Reaction

Chain : A, B, C, D, E
UniProt : Q9UUB1 (RIB4_SCHPO)
Reaction: EC: Evidence:
Physiological Direction:
(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D- ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate 2.5.1.78 PubMed:11856310
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