Brand  (β version)

PDB ID: 2A3U

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Ligands
Code Name Style Show Link
EPE 4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid PoSSuM
MA4 Cyclohexyl-hexyl-beta-D-maltoside PoSSuM
TSL Trans-enamine intermediate of sulbactam PoSSuM
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Structure summary

Code : 2A3U   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of sulbactam bound to E166A variant of SHV-1 beta-lactamase
Release Data : 2005-08-02
Compound :
mol_id molecule chains synonym
1 Beta-lactamase SHV-1 A PIT-2
ec: 3.5.2.6
mutation: E166A
Source :
mol_id organism_scientific expression_system
1 Klebsiella pneumoniae  (taxid:573) Escherichia coli  (taxid:562)
gene: bla, shv1
Authors : Padayatti, P.S., Helfand, M.S., Totir, M.A., Carey, M.P., Carey, P.R., Bonomo, R.A., van den Akker, F.
Keywords : BETA-LACTAMASE, BETA-LACTAM HYDROLASE, PENICILLINASE, DETERGENT BINDING, INHIBITOR DESIGN, COVALENT INTERMEDIATE, hydrolase
Exp. method : X-RAY DIFFRACTION ( 1.34 Å )
Citation :

High Resolution Crystal Structures of the trans-Enamine Intermediates Formed by Sulbactam and Clavulanic Acid and E166A SHV-1 {beta}-Lactamase.

Padayatti, P.S.,Helfand, M.S.,Totir, M.A.  et al.
(2005)  J.Biol.Chem.  280 : 34900 - 34907

PubMed: 16055923
DOI: 10.1074/jbc.M505333200

Reaction

Chain : A
UniProt : P14557 (BLA1_KLEPN)
Reaction: EC: Evidence:
Physiological Direction:
a beta-lactam + H2O = a substituted beta-amino acid 3.5.2.6 PROSITE- ProRule:PRU10101
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