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Ligands
Code Name Style Show Link
C0R Corticosterone
Non-standard Residues
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Glycosylation
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Code : 2A3I   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : Structural and Biochemical Mechanisms for the Specificity of Hormone Binding and Coactivator Assembly by Mineralocorticoid Receptor
Release Data : 2005-07-19
Compound :
mol_id molecule chains synonym
1 Mineralocorticoid receptor A MR
fragment: Mineralocoricoid receptor
mutation: C808S
mol_id molecule chains synonym
2 Nuclear receptor coactivator 1, residues 1430-1441 B NCoA-1, Steroid receptor coactivator-1, SRC-1, RIP160, Hin-2 protein
ec: 2.3.1.48
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: NR3C2, MCR, MLR
expression_system_strain: BL21(DE3)
expression_system_vector_type: PLASMID
expression_system_vector: pET24a
mol_id organism_scientific
2
synthetic: yes
other_details: This sequence occurs naturally in Homo sapiens (humans).
Authors : Li, Y., Suino, K., Daugherty, J., Xu, H.E.
Keywords : transcription factor, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 1.95 Å )
Citation :

Structural and biochemical mechanisms for the specificity of hormone binding and coactivator assembly by mineralocorticoid receptor

Li, Y.,Suino, K.,Daugherty, J.  et al.
(2005)  Mol.Cell  19 : 367 - 380

PubMed: 16061183
DOI: 10.1016/j.molcel.2005.06.026

Chain : A
UniProt : P08235 (MCR_HUMAN)
Reaction : -
Chain : B
UniProt : Q15788 (NCOA1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L- lysyl-[protein] 2.3.1.48 -
-