Brand  (β version)

PDB ID: 1ZXL

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Ligands
Code Name Style Show Link
JP1 N-[3-chloro-4-(4-chloro-2-hydroxyphenoxy)phenyl]morpholine-4-carboxamide PoSSuM
NAD Nicotinamide-adenine-dinucleotide PoSSuM
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Structure summary

Code : 1ZXL   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Synthesis, Biological Activity, and X-Ray Crystal Structural Analysis of Diaryl Ether Inhibitors of Malarial Enoyl ACP Reductase. Part 1:4'-Substituted Triclosan Derivatives
Release Data : 2006-06-13
Compound :
mol_id molecule chains
1 enoyl-acyl carrier reductase A,B
ec: 1.3.1.9
Source :
mol_id organism_scientific organism_common expression_system
1 Plasmodium falciparum  (taxid:5833) Malaria parasite P. falciparum Escherichia coli  (taxid:562)
gene: PfENR
expression_system_strain: BL21(DE3) Codon+-RIL cells
expression_system_vector_type: Plasmid
expression_system_plasmid: pET28a
Authors : Freundlich, J.S., Anderson, J.W., Sarantakis, D., Shieh, H.M., Yu, M., Lucumi, E., Kuo, M., Schiehser, G.A., Jacobus, D.P., Jacobs Jr., W.R., Fidock, D.A., Sacchettini, J.C.
Keywords : OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 3.00 Å )
Citation :

Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-Substituted triclosan derivatives.

Freundlich, J.S.,Anderson, J.W.,Sarantakis, D.  et al.
(2005)  Bioorg.Med.Chem.Lett.  15 : 5247 - 5252

PubMed: 16198563
DOI: 10.1016/j.bmcl.2005.08.044