Het-PDB Navi2 (PDB: 1ZVX)

The number of atoms exceeds 100,000.
So, it can not be displayed here.

Select unit:

Select hetatm:

information

centroid:

interaction residue:

Select chain: Sequence Hide other chain(s)

Data format:

Color scheme of protein:

Ligands
Code	Name	Link
CA	Calcium ion	PoSSuM
FIN	(1r)-1-{[(4'-methoxy-1,1'-biphenyl-4-yl)sulfonyl]amino}-2-methylpropylphosphonic acid	PoSSuM
ZN	Zinc ion	PoSSuM

Non-standard Residues
Code	Name	Show

Glycosylation
Code	Name	Emphasize

Modification
Code	Name	Show

Download interaction data: 1ZVX

Code :

1ZVX PDBj RCSB PDB PDBe

Header :

HYDROLASE

Title :

Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (R-enantiomer)

Release Data :

2006-05-16

Compound :

mol_id	molecule	chains	synonym
1	Neutrophil collagenase	A	Matrix metalloproteinase-8, MMP-8, PMNL collagenase, PMNL-CL
	ec: 3.4.24.34 fragment: catalytic domain of neutrophil collagenase (Residues:80-242)

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli BL21 (taxid:511693)
	gene: MMP8, CLG1 expression_system_strain: BL21 expression_system_plasmid: pSVB30

Authors :

Pochetti, G., Gavuzzo, E., Campestre, C., Agamennone, M., Tortorella, P., Consalvi, V., Gallina, C., Hiller, O., Tschesche, H., Tucker, P.A., Mazza, F.

Keywords :

stereoselective inhibition, phosphonic inhibitors, hydrolase, sulfonamide junction

Exp. method :

X-RAY DIFFRACTION ( 1.87 Å )

Citation :

Structural insight into the stereoselective inhibition of MMP-8 by enantiomeric sulfonamide phosphonates.

Pochetti, G.,Gavuzzo, E.,Campestre, C. et al.
(2006) J.Med.Chem. 49 : 923 - 931

PubMed: 16451058
DOI: 10.1021/jm050787+

X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity

Pavlovsky, A.G.,Williams, M.G.,Ye, Q.Z. et al.
(1999) Protein Sci. 8 : 1455 - 1462

PubMed: 10422833

Two crystal structures of human neutrophil collagenase, one complexed with a primed- and the other with an unprimed-side inhibitor: implications for drug design

Gavuzzo, E.,Pochetti, G.,Mazza, F. et al.
(2000) J.Med.Chem. 43 : 3377 - 3385

PubMed: 10978185
DOI: 10.1021/jm9909589

X-ray structuresof human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design

Grams, F.,Reinemer, P.,Powers, J.C. et al.
(1995) Eur.J.Biochem. 228 : 830 - 841

PubMed: 7737183
DOI: 10.1111/j.1432-1033.1995.tb20329.x

Chain :

UniProt :

P22894 (MMP8_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.	3.4.24.34	-
	-	-

PDB ID: 1ZVX

Hetero Atom Contents

Structure summary

Reaction