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Ligands
Code Name Style Show Link
995 4-methyl-pentanoic acid {1-[4-guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-2-methyl-propyl}-amide
SO4 Sulfate ion
Non-standard Residues
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Glycosylation
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Code : 1ZPB   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with 4-Methyl-pentanoic acid {1-[4-guanidino-1-(thiazole-2-carbonyl)-butylcarbamoyl]-2-methyl-propyl}-amide
Release Data : 2006-04-18
Compound :
mol_id molecule chains synonym
1 Coagulation factor XI A Plasma thromboplastin antecedent, PTA, FXI
ec: 3.4.21.27
fragment: Catalytic Domain
mutation: S452A, T493A, K455A, C500S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Pichia pastoris  (taxid:4922)
gene: F11
expression_system_strain: X-33
Authors : Deng, H., Bannister, T.D., Jin, L., Nagafuji, P., Celatka, C.A., Lin, J., Lazarova, T.I., Rynkiewicz, M.J., Quinn, J., Bibbins, F., Pandey, P., Gorga, J., Babine, R.E., Meyers, H.V., Abdel-Meguid, S.S., Strickler, J.E.
Keywords : FXI, Inhibitor, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.10 Å )
Citation :

Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine

Deng, H.,Bannister, T.D.,Jin, L.  et al.
(2006)  Bioorg.Med.Chem.Lett.  16 : 3049 - 3054

PubMed: 16524727
DOI: 10.1016/j.bmcl.2006.02.052

Chain : A
UniProt : P03951 (FA11_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Selective cleavage of Arg-|-Ala and Arg-|-Val bonds in factor IX to form factor IXa. 3.4.21.27 -
-