Brand  (β version)

PDB ID: 1ZLY

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Ligands
Code Name Style Show Link
DQB 4-[(4-{[(2-amino-4-oxo-3,4-dihydroquinazolin-6-yl)methyl]amino}benzoyl)amino]butanoic acid PoSSuM
GRF 5-O-phosphono-beta-D-ribofuranosylamine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1ZLY   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : The structure of human glycinamide ribonucleotide transformylase in complex with alpha,beta-N-(hydroxyacetyl)-D-ribofuranosylamine and 10-formyl-5,8,dideazafolate
Release Data : 2005-08-23
Compound :
mol_id molecule chains synonym
1 Phosphoribosylglycinamide formyltransferase A GART, GAR transformylase, 5'-phosphoribosylglycinamide transformylase
ec: 2.1.2.2
fragment: residues 808-1010, GART
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: GART, PRGS
expression_system_strain: BL21(DE3) pLysS
expression_system_vector_type: plasmid
expression_system_plasmid: pET17b
Authors : Dahms, T.E.S., Sainz, G., Giroux, E.L., Caperelli, C.A., Smith, J.L.
Keywords : Purine biosynthesis, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.07 Å )
Citation :

The apo and ternary complex structures of a chemotherapeutic target: human glycinamide ribonucleotide transformylase.

Dahms, T.E.,Sainz, G.,Giroux, E.L.  et al.
(2005)  Biochemistry  44 : 9841 - 9850

PubMed: 16026156
DOI: 10.1021/bi050307g

Reaction

Chain : A
UniProt : P22102 (PUR2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate 6.3.4.13 PubMed:20631005, PubMed:2183217
left-to-right PubMed:2183217
(6R)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D- ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)- formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide 2.1.2.2 PubMed:12450384, PubMed:12755606
left-to-right PubMed:12450384
2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate 6.3.3.1 PubMed:20631005, PubMed:2183217
left-to-right PubMed:2183217