Brand  (β version)

PDB ID: 1ZEO

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Ligands
Code Name Style Show Link
C01 (2s)-(4-isopropylphenyl)[(2-methyl-3-oxo-5,7-dipropyl-2,3-dihydro-1,2-benzisoxazol-6-yl)oxy]acetate PoSSuM
Non-standard Residues
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Structure summary

Code : 1ZEO   PDBj   RCSB PDB   PDBe
Header : TRANSCRIPTION
Title : Crystal Structure of Human PPAR-gamma Ligand Binding Domain Complexed with an Alpha-Aryloxyphenylacetic Acid Agonist
Release Data : 2006-04-25
Compound :
mol_id molecule chains synonym
1 Peroxisome proliferator activated receptor gamma A,B PPAR-gamma
fragment: Ligand Binding Domain (LBD), residues 203-477
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: PPARG, NR1C3
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pGEX4T2
Authors : Shi, G.Q., Dropinski, J.F., McKeever, B.M., Adams, A.D., MacNaul, K.L., Elbrecht, A., Berger, J.P., Zhou, G., Doebber, T.W.
Keywords : Nuclear receptor, Ligand Binding Domain, LBD, Alpha helix sandwich, PPAR-RXR heterodimer, TRANSCRIPTION
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Design and Synthesis of alpha-Aryloxyphenylacetic Acid Derivatives: A Novel Class of PPAR alpha/gamma Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity

Shi, G.Q.,Dropinski, J.F.,McKeever, B.M.  et al.
(2005)  J.Med.Chem.  48 : 4457 - 4468

PubMed: 15974597
DOI: 10.1021/jm0502135

Reaction

Chain : A, B
UniProt : P37231 (PPARG_HUMAN)
Reaction : -