Brand  (β version)

PDB ID: 1ZCM

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Ligands
Code Name Style Show Link
C1N N-[(benzyloxy)carbonyl]leucyl-N~1~-[3-fluoro-1-(4-hydroxybenzyl)-2-oxopropyl]leucinamide PoSSuM
CA Calcium ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1ZCM   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Human calpain protease core inhibited by ZLLYCH2F
Release Data : 2006-01-31
Compound :
mol_id molecule chains synonym
1 Calpain 1, large [catalytic] subunit A Calcium-activated neutral proteinase, CANP, Mu-type, muCANP, Micromolar-calpain
ec: 3.4.22.52
fragment: Residues 33 to 353
mutation: G213A
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: CAPN1, CANPL1
expression_system_strain: BL21(DE3)
expression_system_vector_type: plasmid
expression_system_plasmid: pET24d(+)
Authors : Li, Q., Hanzlik, R.P., Weaver, R.F., Schonbrunn, E.
Keywords : Calcium binding, Hydrolase, Protease, Thiol protease
Exp. method : X-RAY DIFFRACTION ( 2.0 Å )
Citation :

Molecular mode of action of a covalently inhibiting peptidomimetic on the human calpain protease core

Li, Q.,Hanzlik, R.P.,Weaver, R.F.  et al.
(2006)  Biochemistry  45 : 701 - 708

PubMed: 16411745
DOI: 10.1021/bi052077b

Reaction

Chain : A
UniProt : P07384 (CAN1_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Broad endopeptidase specificity. 3.4.22.52 PubMed:16411745, PubMed:19617626, PubMed:21531719
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