Brand  (β version)

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
915 (2r)-2-{[(4-fluoro-3-methylphenyl)sulfonyl]amino}-N-hydroxy-2-tetrahydro-2h-pyran-4-ylacetamide
ZN Zinc ion
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show
Code : 1YQY   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Structure of B. Anthrax Lethal factor in complex with a hydroxamate inhibitor
Release Data : 2005-05-31
Compound :
mol_id molecule chains synonym
1 Lethal factor A LF, Anthrax lethal toxin endopeptidase component
ec: 3.4.24.83
fragment: domains II-IV (residues 297-809)
Source :
mol_id organism_scientific expression_system
1 Bacillus anthracis  (taxid:1392) Escherichia coli BL21(DE3)  (taxid:469008)
gene: lef
expression_system_strain: BL21(DE3)
expression_system_vector_type: Plasmid
expression_system_plasmid: pGEX-4T-3
Authors : Shoop, W.L., Xiong, Y., Wiltsie, J., Woods, A., Guo, J., Pivnichny, J.V., Felcetto, T., Michael, B.F., Bansal, A.
Keywords : Toxin, Lethal Factor, inhibitors, hydroxamate, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.3 Å )
Citation :

Anthrax lethal factor inhibition.

Shoop, W.L.,Xiong, Y.,Wiltsie, J.  et al.
(2005)  Proc.Natl.Acad.Sci.Usa  102 : 7958 - 7963

PubMed: 15911756
DOI: 10.1073/pnas.0502159102

Chain : A
UniProt : P15917 (LEF_BACAN)
Reaction: EC: Evidence:
Physiological Direction:
Preferred amino acids around the cleavage site can be denoted BBBBxHx-|-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases. 3.4.24.83 PubMed:14718925, PubMed:9563949
-