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Ligands
Code Name Style Show Link
ZN Zinc ion
MG Magnesium ion
CIO Cilomilast
EDO 1,2-ethanediol
Non-standard Residues
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Glycosylation
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Code : 1XOM   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Cilomilast
Release Data : 2004-12-14
Compound :
mol_id molecule chains synonym
1 cAMP-specific 3',5'-cyclic phosphodiesterase 4D A,B DPDE3, PDE43
ec: 3.1.4.17
fragment: CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 4D
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: PDE4D
expression_system_strain: BL21(DE3)Codon Plus(RIL)
expression_system_vector_type: PLASMID
expression_system_plasmid: pET15b
Authors : Card, G.L., England, B.P., Suzuki, Y., Fong, D., Powell, B., Lee, B., Luu, C., Tabrizizad, M., Gillette, S., Ibrahim, P.N., Artis, D.R., Bollag, G., Milburn, M.V., Kim, S.-H., Schlessinger, J., Zhang, K.Y.J.
Keywords : Phosphodiesterase, PDE, PDE4D, Cilomilast, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 1.55 Å )
Citation :

Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases.

Card, G.L.,England, B.P.,Suzuki, Y.  et al.
(2004)  STRUCTURE  12 : 2233 - 2247

PubMed: 15576036
DOI: 10.1016/j.str.2004.10.004

Chain : A, B
UniProt : Q08499 (PDE4D_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
3',5'-cyclic AMP + H2O = AMP + H(+) 3.1.4.53 PubMed:9371713
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