Brand  (β version)

PDB ID: 1XKK

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
FMM N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine PoSSuM
PO4 Phosphate ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1XKK   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : EGFR kinase domain complexed with a quinazoline inhibitor- GW572016
Release Data : 2004-12-07
Compound :
mol_id molecule chains synonym
1 Epidermal growth factor receptor A Receptor protein-tyrosine kinase ErbB-1
ec: 2.7.1.112
fragment: EGFR kinase domain
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Spodoptera frugiperda  (taxid:7108)
gene: EGFR, ERBB1
expression_system_common: Fall armyworm
expression_system_vector_type: baculovirus
expression_system_vector: pFastBac
Authors : Wood, E.R., Truesdale, A.T., McDonald, O.B., Yuan, D., Hassell, A., Dickerson, S.H., Ellis, B., Pennisi, C., Horne, E., Lackey, K., Alligood, K.J., Rusnak, D.W., Gilmer, T.M., Shewchuk, L.M.
Keywords : EGFR, epidermal growth factor receptor, kinase, Transferase
Exp. method : X-RAY DIFFRACTION ( 2.40 Å )
Citation :

A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells.

Wood, E.R.,Truesdale, A.T.,McDonald, O.B.  et al.
(2004)  Cancer Res.  64 : 6652 - 6659

PubMed: 15374980
DOI: 10.1158/0008-5472.CAN-04-1168

Reaction

Chain : A
UniProt : P00533 (EGFR_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl- [protein] 2.7.10.1 PROSITE-ProRule:PRU10028, PubMed:15374980, PubMed:17349580, PubMed:18046415, PubMed:18227510, PubMed:19560417, PubMed:19563760
-