Brand  (β version)

PDB ID: 1WXY

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Ligands
Code Name Style Show Link
FRK N-[4,5-bis(4-hydroxyphenyl)-1,3-thiazol-2-yl]hexanamide PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1WXY   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal structure of adenosine deaminase ligated with a potent inhibitor
Release Data : 2005-08-16
Compound :
mol_id molecule chains synonym
1 Adenosine deaminase A Adenosine aminohydrolase
ec: 3.5.4.4
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
organ: intestine
Authors : Kinoshita, T.
Keywords : beta barel, HYDROLASE
Exp. method : X-RAY DIFFRACTION ( 2.50 Å )
Citation :

Structural Basis of Compound Recognition by Adenosine Deaminase

Kinoshita, T.,Nakanishi, I.,Terasaka, T.  et al.
(2005)  Biochemistry  44 : 10562 - 10569

PubMed: 16060665
DOI: 10.1021/bi050529e

Reaction

Chain : A
UniProt : P56658 (ADA_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
adenosine + H2O + H(+) = inosine + NH4(+) 3.5.4.4 UniProtKB:P00813
left-to-right
2'-deoxyadenosine + H2O + H(+) = 2'-deoxyinosine + NH4(+) 3.5.4.4 UniProtKB:P00813
left-to-right
cordycepin + H2O + H(+) = 3'-deoxyinosine + NH4(+) - UniProtKB:P00813
left-to-right
Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:12554940
ECO:0000269 | PubMed:14709046
ECO:0000269 | PubMed:15213224
ECO:0000269 | PubMed:16033254
Binds 1 zinc ion per subunit.