Brand  (β version)

PDB ID: 1WCC

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Ligands
Code Name Style Show Link
CIG 2-amino-6-chloropyrazine PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1WCC   PDBj   RCSB PDB   PDBe
Header : TRANSFERASE
Title : screening for fragment binding by X-ray crystallography
Release Data : 2005-01-27
Compound :
mol_id molecule chains synonym
1 CELL DIVISION PROTEIN KINASE 2 A CYCLIN DEPENDENT KINASE 2, P33 PROTEIN KINASE
ec: 2.7.1.37
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN SPODOPTERA FRUGIPERDA  (taxid:7108)
expression_system_cell_line: SF9
expression_system_vector_type: BACULOVIRUS
Authors : Cleasby, A., O'Reilly, M., Hartshorn, M.J., Murray, C.W., Tickle, I.J., Jhoti, H., Frederickson, M.
Keywords : CDK2, KINASE, CELL CYCLE, FRAGMENT SCREENING, TRANSFERASE
Exp. method : X-RAY DIFFRACTION ( 2.20 Å )
Citation :

Fragment-Based Lead Discovery Using X-Ray Crystallography

Hartshorn, M.J.,Murray, C.W.,Cleasby, A.  et al.
(2005)  J.Med.Chem.  48 : 403

PubMed: 15658854
DOI: 10.1021/JM0495778

Reaction

Chain : A
UniProt : P24941 (CDK2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein] 2.7.11.22 PubMed:1396589, PubMed:28666995, PubMed:9030781
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