Het-PDB Navi2 (PDB: 1WCC)

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Ligands
Code	Name		Style	Show	Link
CIG	2-amino-6-chloropyrazine				PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1WCC

Code :

1WCC PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

Screening for fragment binding by X-ray crystallography

Release Data :

2005-01-27

Compound :

mol_id	molecule	chains	synonym
1	CELL DIVISION PROTEIN KINASE 2	A	CYCLIN DEPENDENT KINASE 2, P33 PROTEIN KINASE
	ec: 2.7.1.37

Source :

mol_id	organism_scientific	organism_common	expression_system
1	HOMO SAPIENS (taxid:9606)	HUMAN	SPODOPTERA FRUGIPERDA (taxid:7108)
	expression_system_cell_line: SF9 expression_system_vector_type: BACULOVIRUS

Authors :

Cleasby, A., O'Reilly, M., Hartshorn, M.J., Murray, C.W., Tickle, I.J., Jhoti, H., Frederickson, M.

Keywords :

CDK2, KINASE, CELL CYCLE, FRAGMENT SCREENING, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.20 Å )

Citation :

Fragment-Based Lead Discovery Using X-Ray Crystallography

Hartshorn, M.J.,Murray, C.W.,Cleasby, A. et al.
(2005) J.Med.Chem. 48 : 403 - 413

Chain :

UniProt :

P24941 (CDK2_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)	2.7.11.22	PubMed:1396589, PubMed:24670654, PubMed:28216226, PubMed:28666995, PubMed:9030781
	-
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)	2.7.11.22	PubMed:1396589, PubMed:24670654, PubMed:28666995, PubMed:9030781
	-
Cofactor:	Evidence:	Note:
Mg(2+)	ECO:0000269 \| PubMed:21565702	Binds 2 Mg(2+) ions.

PDB ID: 1WCC