Brand  (β version)

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Ligands
Code Name Link
J77 (methylpyridazine piperidine ethyloxyphenyl)ethylacetate
MYR Myristic acid
Code : 1VBC
Header : VIRUS
Title : POLIOVIRUS (TYPE 3, SABIN STRAIN) (P3/SABIN, P3/LEON/12A(1)B) COMPLEXED WITH R77975
Release Data : 1996-07-11
Compound :
mol_id molecule chains
1 POLIOVIRUS TYPE 3 0
mol_id molecule chains
2 POLIOVIRUS TYPE 3 1
other_details: THE NUMBERING OF THE VP1 RESIDUES HAS BEEN ALTERED TO FACILITATE COMPARISON WITH THE STRUCTURE OF THE MAHONEY STRAIN OF TYPE 1 POLIOVIRUS (PDB ENTRY 2PLV). MAHONEY HAS A TWO RESIDUE INSERTION, RELATIVE TO P3/SABIN, LOCATED IN THE DISORDERED N-TERMINUS OF VP1. THUS THE RESIDUES NUMBERED 24 - 302 IN THIS ENTRY ARE ACTUALLY RESIDUES 22 - 300.
mol_id molecule chains
3 POLIOVIRUS TYPE 3 2
mol_id molecule chains
4 POLIOVIRUS TYPE 3 3
mol_id molecule chains
5 POLIOVIRUS TYPE 3 4
Source :
mol_id organism_scientific
1 Poliovirus type 3 (strains P3/LEON/37 AND P3/LEON 12A[1]B)  (taxid:12088)
strain: P3-SABIN
other_details: P3/SABIN PREPARED FROM A LOW-PASSAGE SEED STOCK OF A PLAQUE ISOLATE (P3/LEON/12A(1)B PLACQUE 411) OBTAINED FROM P.D.MINOR (NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS CONTROL, LONDON)
mol_id organism_scientific
2 Poliovirus type 3 (strains P3/LEON/37 AND P3/LEON 12A[1]B)  (taxid:12088)
strain: P3-SABIN
organ: SEED
other_details: P3/SABIN PREPARED FROM A LOW-PASSAGE SEED STOCK OF A PLAQUE ISOLATE (P3/LEON/12A(1)B PLACQUE 411) OBTAINED FROM P.D.MINOR (NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS CONTROL, LONDON)
mol_id organism_scientific
3 Poliovirus type 3 (strains P3/LEON/37 AND P3/LEON 12A[1]B)  (taxid:12088)
strain: P3-SABIN
organ: SEED
other_details: P3/SABIN PREPARED FROM A LOW-PASSAGE SEED STOCK OF A PLAQUE ISOLATE (P3/LEON/12A(1)B PLACQUE 411) OBTAINED FROM P.D.MINOR (NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS CONTROL, LONDON)
mol_id organism_scientific
4 Poliovirus type 3 (strains P3/LEON/37 AND P3/LEON 12A[1]B)  (taxid:12088)
strain: P3-SABIN
organ: SEED
other_details: P3/SABIN PREPARED FROM A LOW-PASSAGE SEED STOCK OF A PLAQUE ISOLATE (P3/LEON/12A(1)B PLACQUE 411) OBTAINED FROM P.D.MINOR (NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS CONTROL, LONDON)
mol_id organism_scientific
5 Poliovirus type 3 (strains P3/LEON/37 AND P3/LEON 12A[1]B)  (taxid:12088)
strain: P3-SABIN
organ: SEED
other_details: P3/SABIN PREPARED FROM A LOW-PASSAGE SEED STOCK OF A PLAQUE ISOLATE (P3/LEON/12A(1)B PLACQUE 411) OBTAINED FROM P.D.MINOR (NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS CONTROL, LONDON)
Authors : Grant, R.A., Hiremath, C.N., Filman, D.J., Syed, R., Andries, K., Hogle, J.M.
Keywords : VIRUS COAT PROTEIN, HYDROLASE, THIOL PROTEASE, Icosahedral virus, Virus
Exp. method : X-RAY DIFFRACTION ( 2.8 Å )
Citation :

Structures of poliovirus complexes with anti-viral drugs: implications for viral stability and drug design.

Grant, R.A.,Hiremath, C.N.,Filman, D.J.  et al.
(1994)  Curr.Biol.  4 : 784 - 797

PubMed: 7820548
DOI: 10.1016/S0960-9822(00)00176-7

Binding of the Antiviral Drug Win51711 to the Sabin Strain of Type 3 Poliovirus: Structural Comparison with Drug Binding in Rhinovirus 14

Hiremath, C.N.,Grant, R.A.,Filman, D.J.  et al.
(1995)  Acta Crystallogr.,Sect.D  51 : 473

Role of Conformational Transitions in Poliovirus Assembly and Cell Entry

Hogle, J.M.,Syed, R.,Fricks, C.E.  et al.
(1990)  New Aspects of Positive-Strand RNA Viruses  : 199

Structural Factors that Control Conformational Transitions and Serotype Specificity in Type 3 Poliovirus

Filman, D.J.,Syed, R.,Chow, M.  et al.
(1989)  Embo J.  8 : 1567

Myristylation of Picornavirus Capsid Protein Vp4 and its Structural Significance

Chow, M.,Newman, J.F.,Filman, D.  et al.
(1987)  Nature  327 : 482

Three-Dimensional Structure of Poliovirus at 2.9 A Resolution

Hogle, J.M.,Chow, M.,Filman, D.J.
(1985)  Science  229 : 1358

The Nucleotide Sequence of Poliovirus Type 3 Leon 12 A1B: Comparison with Poliovirus Type 1

Stanway, G.,Cann, A.J.,Hauptmann, R.  et al.
(1983)  Nucleic Acids Res.  11 : 5629

Chain : 4
UniProt : P03302 (POLG_POL3L)
Reaction : Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein.
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
NTP + H(2)O = NDP + phosphate.