Brand  (β version)

PDB ID: 1V97

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Ligands
Code Name Style Show Link
ACY Acetic acid PoSSuM
CA Calcium ion PoSSuM
FAD Flavin-adenine dinucleotide PoSSuM
FES Fe2/s2 (inorganic) cluster PoSSuM
FYX 4-(5-pyridin-4-yl-1h-1,2,4-triazol-3-yl)pyridine-2-carbonitrile PoSSuM
GOL Glycerol PoSSuM
MOS Dioxothiomolybdenum(VI) ion PoSSuM
MTE Phosphonic acidmono-(2-amino-5,6-dimercapto-4-oxo-3,7,8a,9,10,10a-hexahydro-4h-8-oxa-1,3,9,10-tetraaza-anthracen-7-ylmethyl)ester PoSSuM
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Structure summary

Code : 1V97   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure of Bovine Milk Xanthine Dehydrogenase FYX-051 bound form
Release Data : 2004-06-22
Compound :
mol_id molecule chains synonym
1 Xanthine dehydrogenase A,B XD
ec: 1.1.1.204
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
Authors : Okamoto, K., Matsumoto, K., Hille, R., Eger, B.T., Pai, E.F., Nishino, T.
Keywords : xanthine dehydrogenase, molybdopterin, FYX-051, reaction intermediate, OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 1.94 Å )
Citation :

The crystal structure of xanthine oxidoreductase during catalysis: Implications for reaction mechanism and enzyme inhibition.

Okamoto, K.,Matsumoto, K.,Hille, R.  et al.
(2004)  Proc.Natl.Acad.Sci.USA  101 : 7931 - 7936

PubMed: 15148401
DOI: 10.1073/pnas.0400973101

Reaction

Chain : A, B
UniProt : P80457 (XDH_BOVIN)
Reaction: EC: Evidence:
Physiological Direction:
H2O + NAD(+) + xanthine = H(+) + NADH + urate 1.17.1.4 PubMed:11005854, PubMed:12421831, PubMed:15148401, PubMed:4352904
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H2O + hypoxanthine + NAD(+) = H(+) + NADH + xanthine 1.17.1.4 PubMed:11005854, PubMed:12421831, PubMed:15148401, PubMed:4352904
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H2O + O2 + xanthine = H2O2 + urate 1.17.3.2 PubMed:11005854, PubMed:12421831, PubMed:15148401, PubMed:4352904
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