Brand  (β version)

PDB ID: 1V1J

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Ligands
Code Name Style Show Link
FA3 2-anhydro-3-fluoro-quinic acid PoSSuM
TRS 2-amino-2-hydroxymethyl-propane-1,3-diol PoSSuM
Non-standard Residues
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Structure summary

Code : 1V1J   PDBj   RCSB PDB   PDBe
Header : LYASE
Title : Crystal structure of type II Dehydroquintae Dehydratase from Streptomyces coelicolor in complex with 3-fluoro
Release Data : 2005-01-26
Compound :
mol_id molecule chains synonym
1 3-DEHYDROQUINATE DEHYDRATASE A,B,C,D,E,F,G,H,I,J,K,L 3-DEHYDROQUINASE, TYPE II DHQASE
ec: 4.2.1.10
Source :
mol_id organism_scientific expression_system
1 STREPTOMYCES COELICOLOR  (taxid:1902) ESCHERICHIA COLI  (taxid:511693)
expression_system_strain: BL21
expression_system_plasmid: PTB361
Authors : Roszak, A.W., Coggins, J.R., Lapthorn, A.J.
Keywords : DHQ, SHIKIMATE, DEHYDROQUINASE, AROMATIC AMINO ACID BIOSYNTHESIS, LYASE
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

(1R,4S,5R)-3-Fluoro-1,4,5-Trihydroxy-2-Cyclohexene-1-Carboxylic Acid: The Fluoro Analogue of the Enolate Intermediate in the Reaction Catalyzed by Type II Dehydroquinases

Frederickson, M.,Roszak, A.W.,Coggins, J.R.  et al.
(2004)  Org.Biomol.Chem.  2 : 1592

PubMed: 15162210
DOI: 10.1039/B404535A

Reaction

Chain : A, B, C, D, E, F, G, H, I, J, K, L
UniProt : P15474 (AROQ_STRCO)
Reaction: EC: Evidence:
Physiological Direction:
3-dehydroquinate = 3-dehydroshikimate + H2O 4.2.1.10 -
-