Het-PDB Navi2 (PDB: 1UZW)

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Ligands
Code	Name	Link
CDH	D-(L-a-aminoadipoyl)-L-cysteinyl-D-isodehydrovaline	PoSSuM
FE2	Fe (II) ion	PoSSuM
SO4	Sulfate ion	PoSSuM

Non-standard Residues
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Glycosylation
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Download interaction data: 1UZW

Code :

1UZW PDBj RCSB PDB PDBe

Header :

OXIDOREDUCTASE

Title :

ISOPENICILLIN N SYNTHASE WITH L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-ISODEHYDROVALINE

Release Data :

2004-06-10

Compound :

mol_id	molecule	chains	synonym
1	ISOPENICILLIN N SYNTHETASE	A	IPNS, ISOPENICILLIN N SYNTHASE
	ec: 1.21.3.1

Source :

mol_id	organism_scientific	organism_common	expression_system
1	EMERICELLA NIDULANS (taxid:162425)	ASPERGILLUS NIDULANS	ESCHERICHIA COLI (taxid:562)
	expression_system_strain: NM554 expression_system_plasmid: PJB703

Authors :

Grummitt, A.R., Rutledge, P.J., Clifton, I.J., Baldwin, J.E.

Keywords :

B-LACTAM ANTIBIOTIC, OXYGENASE, PENICILLIN BIOSYNTHESIS, ANTIBIOTIC BIOSYNTHESIS, OXIDOREDUCTASE

Exp. method :

X-RAY DIFFRACTION ( 1.30 Å )

Citation :

Active Site Mediated Elimination of Hydrogen Fluoride from a Fluorinated Substrate Analogue by Isopenicillin N Synthase

Grummitt, A.R.,Rutledge, P.J.,Clifton, I.J. et al.
(2004) Biochem.J. 382 : 659

PubMed: 15175003
DOI: 10.1042/BJ20040529

Structure of Isopenicillin N Synthase Complexed with Substrate and the Mechanism of Penicillin Formation

Roach, P.L.,Clifton, I.J.,Hensgens, C.M. et al.
(1997) Nature 387 : 827

PubMed: 9194566
DOI: 10.1038/42990

Crystallization and Preliminary X-Ray Diffraction Studies on Recombinant Isopenicillin N Synthase from Aspergillus Nidulans

Roach, P.L.,Schofield, C.J.,Baldwin, J.E. et al.
(1995) Protein Sci. 4 : 1007

PubMed: 7663335

Chain :

UniProt :

P05326 (IPNA_EMENI)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O2 = 2 H2O + isopenicillin N	1.21.3.1	PubMed:11755401, PubMed:28703303, PubMed:3319778
	left-to-right	PubMed:11755401, PubMed:28703303, PubMed:3319778

PDB ID: 1UZW

Hetero Atom Contents

Structure summary

Reaction