Brand  (β version)

PDB ID: 1UTT

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Ligands
Code Name Style Show Link
CA Calcium ion PoSSuM
CP8 2-(1,3-dioxo-1,3-dihydro-2h-isoindol-2-yl) ethyl-4-(4'-ethoxy [1,1'-biphenyl]-4-yl)-4-oxobutanoic acid PoSSuM
HAE Acetohydroxamic acid PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
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Structure summary

Code : 1UTT   PDBj   RCSB PDB   PDBe
Header : HYDROLASE
Title : Crystal Structure of MMP-12 complexed to 2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl-4-(4-ethoxy[1,1-biphenyl]-4-yl)-4-oxobutanoic acid
Release Data : 2004-12-15
Compound :
mol_id molecule chains synonym
1 MACROPHAGE METALLOELASTASE A HME, MATRIX METALLOPROTEINASE-12, MMP-12, MACROPHAGE ELASTASE, ME
ec: 3.4.24.65
fragment: CATALYTIC DOMAIN, RESIDUES 106-264
other_details: COMPLEXED WITH A SMALL MOLECULE INHIBITOR 2-(1,3-DIOXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)ETHYL-4-(4-ETHOXY[1,1-BIPHENYL]-4-YL)-4-OXOBUTANOIC ACID FORMULA C19H19N2O4S, AND ALSO WITH ACETOHYDROXAMIC ACID OR 2-HYDROXYAMINO-2-ETHANAL FORMULA, C2H5NO2
Source :
mol_id organism_scientific organism_common expression_system
1 HOMO SAPIENS  (taxid:9606) HUMAN ESCHERICHIA COLI  (taxid:469008)
expression_system_strain: BL21(DE3)
expression_system_plasmid: PGEMEX1
Authors : Morales, R., Perrier, S., Florent, J.M., Beltra, J., Dufour, S., De Mendez, I., Manceau, P., Tertre, A., Moreau, F., Compere, D., Dublanchet, A.C., O'Gara, M.
Keywords : MACROPHAGE METALLOELASTASE, NON-ZINC CHELATOR, MMP-12, MMP INHIBITOR, HYDROLASE, METALLOPROTEASE
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12.

Morales, R.,Perrier, S.,Florent, J.M.  et al.
(2004)  J. Mol. Biol.  341 : 1063 - 1076

PubMed: 15289103
DOI: 10.1016/j.jmb.2004.06.039

Reaction

Chain : A
UniProt : P39900 (MMP12_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in the B chain of insulin. 3.4.24.65 -
-
Cofactor: Evidence: Note:
Ca(2+) - Binds 4 Ca(2+) ions per subunit.
Zn(2+) - Binds 2 Zn(2+) ions per subunit.