Brand  (β version)

PDB ID: 1UGG

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Ligands
Code Name Style Show Link
ZN Zinc ion PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1UGG   PDBj   RCSB PDB   PDBe
Header : LYASE (OXO-ACID)
Title : HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY SER (A65S)-ORTHORHOMBIC FORM
Release Data : 1997-01-27
Compound :
mol_id molecule chains
1 CARBONIC ANHYDRASE II A
ec: 4.2.1.1
mutation: A65S
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli BL21(DE3)  (taxid:469008)
gene: CAII
expression_system_strain: BL21(DE3)
expression_system_plasmid: PCAM
expression_system_gene: CAII
Authors : Scolnick, L.R., Christianson, D.W.
Keywords : LYASE (OXO-ACID), ACETYLATION, ZINC, POLYMORPHISM, DISEASE MUTATION
Exp. method : X-RAY DIFFRACTION ( 2.2 Å )
Citation :

X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis.

Scolnick, L.R.,Christianson, D.W.
(1996)  Biochemistry  35 : 16429 - 16434

PubMed: 8987974
DOI: 10.1021/bi9617872

Reaction

Chain : A
UniProt : P00918 (CAH2_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
H(+) + hydrogencarbonate = CO2 + H2O 4.2.1.1 PubMed:11327835, PubMed:11802772, PubMed:11831900, PubMed:12056894, PubMed:12171926, PubMed:1336460, PubMed:14736236, PubMed:15300855, PubMed:15453828, PubMed:15667203, PubMed:15865431, PubMed:16106378, PubMed:16214338, PubMed:16290146, PubMed:16686544, PubMed:16759856, PubMed:16807956, PubMed:17127057, PubMed:17251017, PubMed:17314045, PubMed:17330962, PubMed:17346964, PubMed:17540563, PubMed:17588751, PubMed:17705204, PubMed:18024029, PubMed:18162396, PubMed:18266323, PubMed:18374572, PubMed:18481843, PubMed:18618712, PubMed:18640037, PubMed:18942852, PubMed:1909891, PubMed:1910042, PubMed:19170619, PubMed:19186056, PubMed:19206230, PubMed:19520834, PubMed:19778001, PubMed:7761440, PubMed:7901850, PubMed:8218160, PubMed:8262987, PubMed:8399159, PubMed:8451242, PubMed:8485129, PubMed:8639494, PubMed:9265618, PubMed:9398308
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urea = cyanamide + H2O 4.2.1.69 PubMed:10550681, PubMed:11015219
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