Brand  (β version)

PDB ID: 1U3T

Hetero Atom Contents

  The number of atoms exceeds 100,000.
  So, it can not be displayed here.

Select unit:

Select hetatm:   

close
information
centroid:
interaction residue:

Select chain:   Sequence  

Data format:   

Color scheme of protein:

Ligands
Code Name Style Show Link
CCB Cyclobutyl(cyclopentyl)formamide PoSSuM
NAD Nicotinamide-adenine-dinucleotide PoSSuM
ZN Zinc ion PoSSuM
Non-standard Residues
Code Name Show
Glycosylation
Code Name Emphasize
Modification
Code Name Show

Structure summary

Code : 1U3T   PDBj   RCSB PDB   PDBe
Header : OXIDOREDUCTASE
Title : Crystal Structure of Human Alcohol Dehydrogenase Alpha-Alpha Isoform Complexed with N-Cyclopentyl-N-Cyclobutylformamide Determined to 2.5 Angstrom Resolution
Release Data : 2004-10-26
Compound :
mol_id molecule chains synonym
1 Alcohol dehydrogenase alpha chain A,B Alcohol Dehydrogenase Alpha-Alpha Isoform
ec: 1.1.1.1
Source :
mol_id organism_scientific organism_common expression_system
1 Homo sapiens  (taxid:9606) Human Escherichia coli  (taxid:562)
gene: ADH1A
expression_system_strain: DH5-alpha
expression_system_vector_type: PLASMID
expression_system_plasmid: pKK2233
Authors : Gibbons, B.J., Hurley, T.D.
Keywords : OXIDOREDUCTASE
Exp. method : X-RAY DIFFRACTION ( 2.49 Å )
Citation :

Structure of three class I human alcohol dehydrogenases complexed with isoenzyme specific formamide inhibitors

Gibbons, B.J.,Hurley, T.D.
(2004)  Biochemistry  43 : 12555 - 12562

PubMed: 15449945
DOI: 10.1021/bi0489107

Reaction

Chain : A, B
UniProt : P07327 (ADH1A_HUMAN)
Reaction: EC: Evidence:
Physiological Direction:
a primary alcohol + NAD(+) = an aldehyde + NADH + H(+) 1.1.1.1 PubMed:2738060
-
a secondary alcohol + NAD(+) = a ketone + NADH + H(+) 1.1.1.1 PubMed:2738060
-
butan-1-ol + NAD(+) = butanal + NADH + H(+) - PubMed:2738060
-
1-propanol + NAD(+) = propanal + NADH + H(+) - PubMed:2738060
-
Cofactor: Evidence: Note:
Zn(2+) ECO:0000269 | PubMed:11274460
ECO:0000269 | PubMed:15449945
Binds 2 Zn(2+) ions per subunit.