Het-PDB Navi2 (PDB: 1TVO)

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Ligands
Code	Name		Style	Show	Link
FRZ	5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-1h-pyrazolo[3,4-C]pyridazin-3-amine				PoSSuM

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Download interaction data: 1TVO

Code :

1TVO PDBj RCSB PDB PDBe

Header :

TRANSFERASE

Title :

The structure of ERK2 in complex with a small molecule inhibitor

Release Data :

2005-09-13

Compound :

mol_id	molecule	chains	synonym
1	Mitogen-activated protein kinase 1	A	ERK2, Extracellular signal-regulated kinase 2, ERK-2, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, p42-MAPK, ERT1
	ec: 2.7.1.37

Source :

mol_id	organism_scientific	organism_common	expression_system
1	Homo sapiens (taxid:9606)	Human	Escherichia coli (taxid:562)
	expression_system_cell: DH5alfa expression_system_vector_type: plasmid expression_system_plasmid: pGEX-6p-1

Authors :

Kinoshita, T.

Keywords :

KINASE, PROTEIN-INHIBITOR COMPLEX, TRANSFERASE

Exp. method :

X-RAY DIFFRACTION ( 2.50 Å )

Citation :

Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex

Ohori, M.,Kinoshita, T.,Okubo, M. et al.
(2005) Biochem.Biophys.Res.Commun. 336 : 357 - 363

Chain :

UniProt :

P28482 (MK01_HUMAN)

Reaction:	EC:	Evidence:
Reaction:	Physiological Direction:	Evidence:
ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]	2.7.11.24	-
	-	-
ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]	2.7.11.24	-
	-	-

PDB ID: 1TVO