Brand  (β version)

PDB ID: 1TVK

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Ligands
Code Name Style Show Link
EP Epothilone a PoSSuM
GDP Guanosine-5'-diphosphate PoSSuM
GTP Guanosine-5'-triphosphate PoSSuM
Non-standard Residues
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Glycosylation
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Structure summary

Code : 1TVK   PDBj   RCSB PDB   PDBe
Header : CELL CYCLE, STRUCTURAL PROTEIN
Title : The binding mode of epothilone A on a,B-tubulin by electron crystallography
Release Data : 2004-09-14
Compound :
mol_id molecule chains
1 Tubulin alpha chain A
other_details: see REMARK 400
mol_id molecule chains
2 Tubulin beta chain B
other_details: see REMARK 400
Source :
mol_id organism_scientific organism_common
1 Bos taurus  (taxid:9913) Cattle
organ: Brain
mol_id organism_scientific organism_common
2 Bos taurus  (taxid:9913) Cattle
organ: Brain
Authors : Nettles, J.H., Li, H., Cornett, B., Krahn, J.M., Snyder, J.P., Downing, K.H.
Keywords : epothilone; taxol; ligand interactions, CELL CYCLE, STRUCTURAL PROTEIN
Exp. method : ELECTRON CRYSTALLOGRAPHY ( 2.89 Å )
Citation :

The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography

Nettles, J.H.,Li, H.,Cornett, B.  et al.
(2004)  Science  305 : 866 - 869

PubMed: 15297674
DOI: 10.1126/science.1099190

Reaction

Chain : A
UniProt : P02550 (TBA1A_PIG)
Reaction: EC: Evidence:
Physiological Direction:
GTP + H2O = GDP + phosphate + H(+) - UniProtKB:P68363
left-to-right
Cofactor: Evidence: Note:
Mg(2+) ECO:0000250 | UniProtKB:P68363
-
Chain : B
UniProt : P02554 (TBB_PIG)
Reaction : -
Cofactor: Evidence: Note:
Mg(2+) ECO:0000250 | UniProtKB:P68363
-