PDB ID: 1TSD
Hetero Atom Contents
The number of atoms exceeds 100,000. So, it can not be displayed here.
Select unit:
Select hetatm:
Select chain: Sequence
Data format:
Color scheme of protein:
Code | Name | Style | Show | Link | |
---|---|---|---|---|---|
BME | Beta-mercaptoethanol | PoSSuM | |||
F89 | S)-2-(5(((1,2-dihydro-3-methyl-1-oxobenzo(f)quinazolin-9-yl)methyl)amino)1-oxo-2-isoindolinyl)glutaric acid | PoSSuM | |||
UMP | 2'-deoxyuridine 5'-monophosphate | PoSSuM |
Code | Name | Show |
---|
Code | Name | Emphasize |
---|
Code | Name | Show |
---|---|---|
FMT | Formic acid |
Download interaction data: 1TSD
Structure summary
Code : | 1TSD PDBj RCSB PDB PDBe | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Header : | TRANSFERASE (METHYLTRANSFERASE) | ||||||||||||
Title : | THYMIDYLATE SYNTHASE COMPLEX WITH 2'-DEOXYURIDINE 5'-MONOPHOSPHATE (DUMP) AND FOLATE ANALOG 1843U89 | ||||||||||||
Release Data : | 1996-01-29 | ||||||||||||
Compound : |
|
||||||||||||
Source : |
|
||||||||||||
Authors : | Weichsel, A., Montfort, W.R. | ||||||||||||
Keywords : | DUMP, 1843U89, TRANSFERASE (METHYLTRANSFERASE) | ||||||||||||
Exp. method : | X-RAY DIFFRACTION ( 1.95 Å ) | ||||||||||||
Citation : |
Ligand-induced distortion of an active site in thymidylate synthase upon binding anticancer drug 1843U89.
Weichsel, A.,Montfort, W.R.
PubMed: 8846221 Promotion of Purine Nucleotide Binding to Thymidylate Synthase by a Potent Folate Analogue Inhibitor, 1843U89
Weichsel, A.,Montfort, W.R.,Ciesla, J.
et al.
Structure, Multiple Site Binding, and Segmental Accommodation in Thymidylate Synthase on Binding Dump and an Anti-Folate
Montfort, W.R.,Perry, K.M.,Fauman, E.B.
et al.
|
Reaction
Chain : | A, B |
---|---|
UniProt : | P00470 (multiple entry names are found) |
Reaction : | - |