Brand  (β version)

PDB ID: 1THE

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Ligands
Code Name Style Show Link
0E6 Amino{[(4s)-4-{[(benzyloxy)carbonyl]amino}-5-{[(2s)-1-(benzyloxy)-4-chloro-3-oxobutan-2-yl]amino}-5-oxopentyl]amino}methaniminium PoSSuM
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Structure summary

Code : 1THE   PDBj   RCSB PDB   PDBe
Header : HYDROLASE/HYDROLASE INHIBITOR
Title : CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN
Release Data : 1996-03-10
Compound :
mol_id molecule chains synonym
1 Cathepsin B A,B Cathepsin B1, RSG-2, Cathepsin B light chain, Cathepsin B heavy chain
ec: 3.4.22.1
mutation: S115A
other_details: RECOMBINANT RAT ENZYME
Source :
mol_id organism_scientific organism_common expression_system
1 Rattus norvegicus  (taxid:10116) Brown rat,rat,rats Saccharomyces cerevisiae  (taxid:4932)
gene: CDNA, Ctsb
expression_system_common: Baker's yeast
expression_system_vector_type: PLASMID
Authors : Huber, C.P., Jia, Z.
Keywords : THIOL PROTEASE, Glycoprotein, Protease, HYDROLASE-HYDROLASE INHIBITOR complex
Exp. method : X-RAY DIFFRACTION ( 1.9 Å )
Citation :

Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design.

Jia, Z.,Hasnain, S.,Hirama, T.  et al.
(1995)  J.Biol.Chem.  270 : 5527 - 5533

PubMed: 7890671
DOI: 10.1074/jbc.270.10.5527

Crystallization of Recombinant Rat Cathepsin B

Lee, X.,Ahmed, F.R.,Hirama, T.  et al.
(1990)  J.Biol.Chem.  265 : 5950

Reaction

Chain : A, B
UniProt : P00787 (CATB_RAT)
Reaction: EC: Evidence:
Physiological Direction:
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C- terminal dipeptides. 3.4.22.1 PubMed:1639824
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